Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	115903
Country	China

Category	Radiology, Nuclear Medicine & Medical Imaging
Manuscript Type	Retrospective Cohort Study
Article Title	Machine learning and radiomics for differentiating severe from moderately severe acute necrotizing pancreatitis on contrast-enhanced computed tomography
Manuscript Source	Unsolicited Manuscript
All Author List	Yue Feng, Xi-Hao Hu and Bo Xiao
Funding Agency and Grant Number	Funding Agency Grant Number Chongqing Science and Health Joint Medical Research Project 2024MSXM165 Chongqing Bishan District Science and Technology Bureau Project BSKJ2024062 Leading Scientific Research and Innovation Team Project of Bishan Hospital of Chongqing BYKY-CX2024001
Corresponding Author	Bo Xiao, Associate Professor, Chief, Chief Physician, Director, MD, Department of Radiology, Bishan Hospital of Chongqing Medical University, Bishan Hospital of Chongqing, No. 9 Shuangxing Avenue, Bishan District, Chongqing 402760, China. xiaoboimaging@163.com
Key Words	Acute necrotizing pancreatitis; Peripancreatic necrotic collections; Radiomics; Machine learning; Contrast-enhanced computed tomography; Severe acute pancreatitis; Differential diagnosis
Core Tip	Acute necrotizing pancreatitis (ANP), a more severe form of acute pancreatitis, requires early diagnosis and accurate severity stratification for optimal patient prognosis and treatment. This study demonstrates that radiomics based on contrast-enhanced computed tomography of both pancreatic parenchyma and peripancreatic necrotic collections, combined with machine learning algorithms, can effectively differentiate between severe and moderately severe ANP. This model may serve as a valuable adjunct clinical decision support tool, and its refined classification of ANP into severe and moderately severe categories could help optimize resource allocation and improve patient triage.
Citation	Feng Y, Hu XH, Xiao B. Machine learning and radiomics for differentiating severe from moderately severe acute necrotizing pancreatitis on contrast-enhanced computed tomography. World J Gastrointest Surg 2026; In press

Received	2025-10-31 14:23
Peer-Review Started	2025-10-31 14:23
First Decision by Editorial Office Director	2025-12-05 09:34
Return for Revision	2025-12-05 20:17
Revised	2025-12-16 00:01
Publication Fee Transferred	2025-12-25 07:16
Second Decision by Editor	2026-02-04 02:52
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-04 05:04
Articles in Press	2026-02-04 05:04
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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