Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	115905
Country	China

Category	Anesthesiology
Manuscript Type	Basic Study
Article Title	Activation of interleukin-33/suppression of tumorigenicity 2 signaling contributes to gallbladder carcinoma-induced chronic pain
Manuscript Source	Unsolicited Manuscript
All Author List	Xian-Xiu Ge, Xin-Ming Dong, Yang Yang, Wen Zhang, Wei Zhou and Xue-Ting Deng
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82171222
Corresponding Author	Xue-Ting Deng, Medical Center for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical University, No. 121 Jiangjiayuan, Nanjing 210011, Jiangsu Province, China. xtdeng@njmu.edu.cn
Key Words	Interleukin-33; Gallbladder carcinoma; Chronic cancer-related pain; Spinal cord; Proinflammatory cytokines
Core Tip	This study revealed the role of spinal interleukin-33 (IL-33)/suppression of tumorigenicity 2 (ST2) signaling in the pathogenesis of gallbladder carcinoma (GBC)-induced chronic pain. IL-33/ST2 activation is critical for the genesis and maintenance of GBC-induced chronic pain. Blockade of IL-33/ST2 signaling in the spinal cord results in a significant reduction in pain-related behaviors as well as the proinflammatory cytokine levels in rodents with GBC-induced chronic pain. This study suggested that targeting IL-33/ST2 signaling may relieve chronic cancer pain due to gallbladder carcinoma.
Citation	Ge XX, Dong XM, Yang Y, Zhang W, Zhou W, Deng XT. Activation of interleukin-33/suppression of tumorigenicity 2 signaling contributes to gallbladder carcinoma-induced chronic pain. World J Gastrointest Oncol 2026; In press

Received	2025-10-29 16:21
Peer-Review Started	2025-10-29 16:21
First Decision by Editorial Office Director	2025-12-02 10:09
Return for Revision	2025-12-03 07:29
Revised	2025-12-09 02:49
Publication Fee Transferred	2025-12-11 01:12
Second Decision by Editor	2026-01-16 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-16 06:56
Articles in Press	2026-01-16 06:56
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Typeset the Manuscript

ISSN	1948-5204 (online)
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