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Articles in Press
1/8/2026 7:06:16 AM | Browse: 9 | Download: 0
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Retrospective analysis cognitive function changes in elderly depressive patients after gastrointestinal tumor surgery and exploration of cholinergic mechanism
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wen Li, Zhen-Yu Ye and Jian-Qin Zhao |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82372636 |
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| Corresponding Author |
Jian-Qin Zhao, Associate Chief Nurse, Department of General Surgery, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou 215004, Jiangsu Province, China. zhaojianqin2023@163.com |
| Key Words |
Post-operative cognitive dysfunction; Older people with depression; Gastrointestinal tumor; Cholinergic system; Retrospective study |
| Core Tip |
Data from 95 older patients with depression who had gastrointestinal tumor surgery, were retrospectively analyzed, and there was an incidence of post-operative cognitive dysfunction (POCD) of 36.84%, seven days post-operatively. Advanced age, high pre-operative Hamilton Depression Rating Scale score, long duration of surgery, intra-operative anticholinergics, and high post-operative interleukin-6 (IL-6) change rate were independent risk factors for POCD. Mechanistically, pre-operative depression exacerbated systemic inflammation (via IL-6) and impaired cholinergic function (via reduced cholinesterase), jointly increasing the risk of POCD, with the two mediating effects accounting for 19.7% and 17.2% of the total effect, respectively. These findings provide a basis for the targeted prevention of POCD. |
| Citation |
Li W, Ye ZY, Zhao JQ. Retrospective analysis cognitive function changes in elderly depressive patients after gastrointestinal tumor surgery and exploration of cholinergic mechanism. World J Gastrointest Surg 2026; In press |
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Received |
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2025-11-28 10:00 |
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Peer-Review Started |
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2025-11-28 10:00 |
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First Decision by Editorial Office Director |
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2025-12-19 07:57 |
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Return for Revision |
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2025-12-19 07:57 |
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Revised |
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2025-12-26 07:53 |
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Publication Fee Transferred |
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2025-12-29 14:19 |
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Second Decision by Editor |
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2026-01-08 02:47 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-01-08 07:06 |
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Articles in Press |
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2026-01-08 07:06 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
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