Publication Name	World Journal of Experimental Medicine
Manuscript ID	115926
Country	South Korea

Category	Medical Informatics
Manuscript Type	Letter to the Editor
Article Title	Targeted meta-analysis on a triple-strain probiotic for diabetes
Manuscript Source	Unsolicited Manuscript
All Author List	Haewon Byeon
Funding Agency and Grant Number	Funding Agency Grant Number Basic Science Research Program Through the National Research Foundation of Korea Funded by the Ministry of Education NRF-RS-2023-00237287
Corresponding Author	Haewon Byeon, Associate Professor, Director, PhD, Worker's Care & Digital Health Lab, Department of Future Technology, Korea University of Technology and Education, 1600, Chungjeol-ro, Cheonan 31253, South Korea. bhwpuma@naver.com
Key Words	Probiotic combination; Diabetes; Metabolic parameters; Heterogeneity; Generalizability
Core Tip	The meta-analysis by Dubey et al provides focused evidence on a specific triple probiotic combination (Lactobacillus acidophilus, Lactobacillus casei, Bifidobacterium bifidum) for diabetes management. The key finding is that this specific formulation significantly improves glycemic control, reduces oxidative stress and inflammation, and beneficially modulates lipid profiles. Unlike broader meta-analyses that pool various probiotics, this study’s specificity offers direct clinical relevance, suggesting this combination is a viable adjuvant therapy. However, the high heterogeneity in some results and the small number of included studies mean these promising findings should be interpreted with caution. Larger, well-designed randomized controlled trials are needed to solidify these conclusions.
Citation	Byeon H. Targeted meta-analysis on a triple-strain probiotic for diabetes. World J Exp Med 2025; In press

Received	2025-10-29 16:07
Peer-Review Started	2025-10-29 16:08
First Decision by Editorial Office Director	2025-11-06 09:03
Return for Revision	2025-11-06 09:03
Revised	2025-11-07 12:47
Publication Fee Transferred
Second Decision by Editor	2025-12-29 02:32
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-29 03:50
Articles in Press	2025-12-29 03:50
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-315x (online)
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