Publication Name	World Journal of Gastroenterology
Manuscript ID	115941
Country	Spain

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Long-term clinical outcomes with filgotinib in ulcerative colitis: 12-month results from the FILGUITO study
Manuscript Source	Invited Manuscript
All Author List	Antonio M Caballero-Mateos, Claudio Trigo-Salado, Álvaro Suárez-Toribio, María del Mar Martín-Rodríguez, Francisco J Rodríguez-González, Teresa Valdés-Delgado, Héctor Pallarés-Manrique, Ana María Trapero-Martínez, Raúl Olmedo-Martin, Cristina Bailón-Gaona, José Manuel Benitez Cantero, B Gros, Antonia Sáez-Díaz and Álvaro Hernández-Martínez
Funding Agency and Grant Number
Corresponding Author	Antonio M Caballero-Mateos, MD, PhD, Department of Internal Medicine, Santa Ana Hospital, Motril, Granada, Spain, Avenida Enrique Martín Cuevas s/n,, Motril 18600, Spain. ogy1492@hotmail.com
Key Words	Filgotinib; Ulcerative colitis; JAK inhibitor; Real-world evidence; Effectiveness; Safety
Core Tip	This multicenter real-world study (FILGUITO) evaluated 12-month effectiveness and safety of filgotinib in 104 patients with moderate-to-severe ulcerative colitis, predominantly biologic-experienced. Clinical remission remained sustained at approximately 60% throughout follow-up, with clinical-biochemical remission reaching 38.6% at 6 months. Fecal calprotectin decreased significantly from 2000 μg/g to 153 μg/g at 12 months. Treatment discontinuation occurred in 22.1% of patients. Patients with fewer prior biologic failures showed superior outcomes. Filgotinib demonstrated sustained effectiveness and favorable safety over 12 months, with optimal benefit when used earlier in the treatment algorithm.
Citation	Caballero-Mateos AM, Trigo-Salado C, Suárez-Toribio Á, Martín-Rodríguez MDM, Rodríguez-González FJ, Valdés-Delgado T, Pallarés-Manrique H, Trapero-Martínez AM, Olmedo-Martin R, Bailón-Gaona C, Benitez Cantero JM, Gros B, Sáez-Díaz A, Hernández-Martínez Á. Long-term clinical outcomes with filgotinib in ulcerative colitis: 12-month results from the FILGUITO study. World J Gastroenterol 2025; In press

Received	2025-10-29 14:39
Peer-Review Started	2025-10-29 14:39
First Decision by Editorial Office Director	2025-11-19 10:59
Return for Revision	2025-11-19 10:59
Revised	2025-11-19 22:03
Publication Fee Transferred
Second Decision by Editor	2025-12-18 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-18 07:36
Articles in Press	2025-12-18 07:36
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com