Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	115944
Country	Türkiye

Category	Anesthesiology
Manuscript Type	Editorial
Article Title	Does anesthesia choice shape oncologic destiny in gastric cancer surgery?
Manuscript Source	Invited Manuscript
All Author List	Oguzhan Arun and Funda Arun
Funding Agency and Grant Number
Corresponding Author	Oguzhan Arun, MD, PhD, Professor, Department of Anesthesiology and Reanimation, Selcuk University Faculty of Medicine, Alaaddin Keykubat Kampus, Konya 42130, Türkiye. oguzarun@selcuk.edu.tr
Key Words	Anesthesia; Gastric cancer; Propofol; Sevoflurane; Total intravenous anesthesia
Core Tip	Anesthetic choice in gastric cancer surgery extends beyond technical preference, potentially influencing immune function, stress response, and oncologic outcomes. Propofol-based total intravenous anesthesia demonstrates promising molecular and clinical anti-tumor properties-modulating microRNAs, enhancing natural killer cell activity, and improving post-operative recovery-while sevoflurane, though traditionally considered neutral, shows emerging immunoregulatory and gene-expression effects. Current evidence, including the recent Wang et al study, suggests both agents yield comparable perioperative safety and survival outcomes; however, their distinct molecular profiles highlight anesthesia as a modifiable element in personalized cancer care. Future biomarker-driven research is essential to clarify when and how anesthetic selection might influence long-term oncologic prognosis.
Citation	Arun O, Arun F. Does anesthesia choice shape oncologic destiny in gastric cancer surgery? World J Gastrointest Oncol 2025; In press

Received	2025-10-29 05:42
Peer-Review Started	2025-10-29 05:43
First Decision by Editorial Office Director	2025-11-06 08:51
Return for Revision	2025-11-06 08:51
Revised	2025-11-17 14:52
Publication Fee Transferred
Second Decision by Editor	2025-12-09 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-10 02:35
Articles in Press	2025-12-10 02:35
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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