Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	115954
Country	China

Category	Surgery
Manuscript Type	Case Report
Article Title	Giant serosal cavernous hemangioma of the ileum: A case report and review of literature
Manuscript Source	Unsolicited Manuscript
All Author List	Hai-Bo Si, Hao-Jie Qin, Yong-Peng Wang and Fang-Fang Nie
Funding Agency and Grant Number	Funding Agency Grant Number Beijing Science and Technology Innovation Medical Development Foundation No. KC2021-JX-0186-139 Chinese Anti-Cancer Society-Hengrui PARP-Inhibitor Oncology Research Fund
Corresponding Author	Yong-Peng Wang, Department of Gynecology, Cancer Hospital of Dalian University of Technology/Liaoning Cancer Hospital and Institute/Cancer Hospital of China Medical University, No. 44 Xiaoheyan Road, Dadong District, Shenyang 110042, Liaoning Province, China. wangyongpeng@cancerhosp-ln-cmu.com
Key Words	Giant cavernous hemangioma; Ileum; Serosal layer; Laparoscopic conversion; Case report
Core Tip	This article reports a rare case of ileal serosal cavernous hemangioma. The lesion is fundamentally a vascular malformation rather than a true neoplasm, associated with aberrant activation of the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin signaling pathway due to TEK/PIK3CA gene mutations. Although benign, its pseudo-infiltrative growth pattern and potential risk of delayed rupture can lead to severe complications. This case highlights that even asymptomatic lesions should be evaluated based on their long-term risks, and surgical resection remains the primary curative strategy. Enhanced clinical awareness is crucial for early diagnosis and intervention.
Citation	Si HB, Q HJ, Wang YP, Nie FF. Giant serosal cavernous hemangioma of the ileum: A case report and review of literature. World J Gastrointest Surg 2026; In press

Received	2025-10-31 10:05
Peer-Review Started	2025-10-31 10:05
First Decision by Editorial Office Director	2025-12-11 09:50
Return for Revision	2025-12-13 02:42
Revised	2025-12-18 11:55
Publication Fee Transferred	2025-12-25 09:47
Second Decision by Editor	2026-02-03 02:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-03 06:50
Articles in Press	2026-02-03 06:50
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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