Publication Name	World Journal of Gastroenterology
Manuscript ID	115957
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Chaihu-Shugan-San ameliorates chronic atrophic gastritis by inhibiting nuclear factor-kappa B-mediated inflammation and apoptosis
Manuscript Source	Unsolicited Manuscript
All Author List	Jin Song, Dan-Yan Li, Xiao-Li Zhang, Sha-Sha He, Ning Wang, Hui-Cun Zhang, Yun-Jing Bai, Bo Li and Sheng-Sheng Zhang
Funding Agency and Grant Number	Funding Agency Grant Number Special Funds of Beijing Institute of Chinese Medicine No. YJS-2024-20
Corresponding Author	Sheng-Sheng Zhang, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, No. 23 Meishuguanhoujie, Dongcheng District, Beijing 100010, China. zhss2000@hotmail.com
Key Words	Chronic atrophic gastritis; Chaihu-Shugan-San; Inflammation; Apoptosis; Nuclear factor-kappa B
Core Tip	Our study demonstrated that Chaihu-Shugan-San (CSS) restored body weight, mitigated gastric tissue histology, and alleviated intestinal metaplasia in rats with chronic atrophic gastritis, reduced levels of inflammatory cytokines, and promoted antiapoptotic pathways. CSS was shown to downregulate the nuclear factor-kappa B signaling proteins, providing insights into its mechanism of action in protection against chronic atrophic gastritis development.
Citation	Song J, Li DY, Zhang XL, He SS, Wang N, Zhang HC, Bai YJ, Li B, Zhang SS. Chaihu-Shugan-San ameliorates chronic atrophic gastritis by inhibiting nuclear factor-kappa B-mediated inflammation and apoptosis. World J Gastroenterol 2026; In press

Received	2025-11-03 07:47
Peer-Review Started	2025-11-03 07:47
First Decision by Editorial Office Director	2025-11-21 10:09
Return for Revision	2025-11-21 10:09
Revised	2025-12-04 02:14
Publication Fee Transferred	2025-12-05 01:38
Second Decision by Editor	2026-01-07 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-07 08:30
Articles in Press	2026-01-07 08:30
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Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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