Publication Name	World Journal of Gastroenterology
Manuscript ID	115958
Country	China

Category	Computer Science, Artificial Intelligence
Manuscript Type	Letter to the Editor
Article Title	wisdom in historical medicine: promise and challenges
Manuscript Source	Invited Manuscript
All Author List	Yu-Xin Wang, Shi-Chao Su and Jia-Yu Liu
Funding Agency and Grant Number
Corresponding Author	Jia-Yu Liu, Senior Department of Neurosurgery, Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China. liujiayu@pku.edu.cn
Key Words	Artificial intelligence; Artificial wisdom; Historical investigation; Medical mystery; Chat Generative Pre-Trained Transformer; Guillain-Barré syndrome
Core Tip	Zhou et al’s study demonstrates that while Chat Generative Pre-Trained Transformer can generate plausible hypotheses for historical medical events, it often suffers from citation inaccuracies and overconfidence. The artificial wisdom framework, which integrates artificial intelligence outputs with human expertise, revealed that Campylobacter jejuni-induced Guillain-Barré syndrome is a more credible cause of Alexander the Great’s death than typhoid fever. This approach highlights the importance of human oversight in artificial intelligence-assisted research, offering a model for responsible historical and medical analyses.
Citation	Wang YX, Su SC, Liu JY. Artificial wisdom in historical medicine: Promise and challenges. World J Gastroenterol 2026; In press

Received	2025-10-30 05:46
Peer-Review Started	2025-10-30 05:47
First Decision by Editorial Office Director	2025-12-09 09:47
Return for Revision	2025-12-09 09:47
Revised	2025-12-11 18:15
Publication Fee Transferred
Second Decision by Editor	2026-02-02 03:01
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-03 02:01
Articles in Press	2026-02-03 02:01
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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