Publication Name	World Journal of Psychiatry
Manuscript ID	115960
Country	China

Category	Psychology
Manuscript Type	Basic Study
Article Title	Yueju pill regulates the mechanism of SIRT1/FoxO3a-mediated autophagy pathway against depression
Manuscript Source	Unsolicited Manuscript
All Author List	Li-Li Gao, An-Wen Huang, Da He, Jia-Zhen Tong, Wei-Feng Hong, Xu-Jie Zhuang, Xin-Ming Wu, Yang-Hui Zhou and Min Lin
Funding Agency and Grant Number	Funding Agency Grant Number the Fujian Research and Training Grants for Young and Middle-aged Leaders in Healthcare (Minweirenhan 2023) 26 the Medical Innovation Project of Fujian Provincial Health Commission 2022CXA052 the Fujian University of Traditional Chinese Medicine Major Scientific and Technological Innovation “Open Competition Mechanism to Select the Best Candidates” Special Project XJB2022003-3 the Natural Science Foundation of Fujian Province 2024J01733
Corresponding Author	Li-Li Gao, PhD, Department of Neurology, The second Affiliated Hospital of Fujian Traditional Chinese Medical University, No. 282, Wusi Road, Fuzhou 350003, Fujian Province, China. gaolili2025@yeah.net
Key Words	Yueju pill; Chronic unpredictable mild stress; SIRT1/FoxO3a; Autophagy; Antidepressant
Core Tip	Depression is a mental disorder primarily characterized by low mood, with a gradually increasing incidence in modern society. The exploration of antidepressants derived from traditional Chinese medicinal substances has therefore become a research hotspot. Although previous studies indicate that Yueju pill is effective in treating mood disorder-related syndromes, its potential antidepressant mechanism via regulation of the SIRT1/FoxO3a-mediated autophagy pathway has not been reported. Therefore, this study employed a chronic unpredictable mild stress rat model and investigated the antidepressant mechanism of Yueju pill through targeted pathway intervention.
Citation	Gao LL, Huang AW, He D, Tong JZ, Hong WF, Zhuang XJ, Wu XM, Zhou YH, Lin M. Yueju pill regulates the mechanism of SIRT1/FoxO3a-mediated autophagy pathway against depression. World J Psychiatry 2026; In press

Received	2025-11-18 09:25
Peer-Review Started	2025-11-18 09:25
First Decision by Editorial Office Director	2025-12-05 06:56
Return for Revision	2025-12-05 06:56
Revised	2025-12-21 07:29
Publication Fee Transferred
Second Decision by Editor	2026-01-09 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-09 06:18
Articles in Press	2026-01-09 06:18
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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