Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	115963
Country	Egypt

Category	Pediatrics
Manuscript Type	Systematic Reviews
Article Title	Ultrasound hepatic elastography: A non-invasive indicator of insulin resistance in the pediatric population: A systematic review
Manuscript Source	Invited Manuscript
All Author List	Reem M Elbeltagi, Nermin K Saeed, Adel S Bediwy and Mohammed Al-Beltagi
Funding Agency and Grant Number
Corresponding Author	Mohammed Al-Beltagi, Chairman, Consultant, Full Professor, Head, MD, PhD, Professor, Senior Researcher, Department of Pediatrics, Faculty of Medicine, Tanta University, 1 Hassan Radwan Street, Tanta 31511, Algharbia, Egypt. mohamed.elbeltagi@med.tanta.edu.eg
Key Words	Pediatric metabolic dysfunction-associated steatotic liver disease; Insulin resistance; Liver stiffness measurement; Controlled attenuation parameter; Transient elastography; Metabolic syndrome; Non-invasive biomarkers
Core Tip	This systematic review and meta-analysis highlight that ultrasound-based hepatic elastography, through liver stiffness measurement and controlled attenuation parameter, provides a reliable, non-invasive reflection of insulin resistance (IR) in children and adolescents with metabolic dysfunction-associated steatotic liver disease. Controlled attenuation parameter effectively identifies early hepatic fat accumulation, while liver stiffness measurement detects fibrotic progression linked to chronic IR. The strongest correlations with adipose tissue IR and metabolic score-IR emphasize that elastography captures systemic metabolic dysfunction beyond the liver. These findings support its integration into pediatric screening and monitoring to guide early intervention and prevention of IR and steatotic liver disease.
Citation	Elbeltagi RM, Saeed NK, Bediwy AS, Al-Beltagi M. Ultrasound hepatic elastography: A non-invasive indicator of insulin resistance in the pediatric population: A systematic review. World J Clin Pediatr 2026; In press

Received	2025-10-30 05:35
Peer-Review Started	2025-10-30 05:35
First Decision by Editorial Office Director	2025-11-30 01:33
Return for Revision	2025-11-30 01:33
Revised	2025-12-03 10:30
Publication Fee Transferred
Second Decision by Editor	2026-02-05 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-05 08:01
Articles in Press	2026-02-05 08:01
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2219-2808 (online)
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