| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Wuda granules target estrogen receptors and modulate gut microbiota to alleviate postoperative ileus: A multi-omics perspective
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Tao Wang, Yi-Hua Xu, Yang-Hui Ou, Wen-Jun Xiong, Li-Jie Luo, Jin Li, Yao-Hui Peng, Yan Chen, Hai-Ping Zeng, Yang Yu, Hai-Peng Tang, Fei Wang, Hong-Liang Yao and Wei Wang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82205109, 82304895 |
| Youth Science and Technology Talent Cultivation Program 2025-2026 of Guangdong Association for Science and Technology |
SKXRC2025212 |
| Guangzhou Science and Technology Bureau Basic and Applied Basic Research Project, |
2025A04J3690 |
| Research Project of Guangdong Provincial Bureau of Traditional Chinese Medicine |
20261103 |
| Young and Middle-aged Backbone Cultivation Project of the First Affiliated Hospital of Guangzhou University of Chinese Medicine |
09005650055 |
| Supporting Scientific Research Fund of the First Affiliated Hospital of Guangzhou University of Chinese Medicine |
09005647001 |
| Guangzhou Basic and Applied Basic Research Foundation |
2023A04J0461 |
|
| Corresponding Author |
Wei Wang, Department of Gastrointestinal Surgery, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Courtyard 16, Jichang Road, Guangzhou 510405, Guangdong Province, China. wangwei16400@163.com |
| Key Words |
Wuda granule; Postoperative ileus; Anti-inflammatory; Estrogen receptors; Gut microbiota |
| Core Tip |
Postoperative ileus (POI) is a frequent postsurgical complication. This study shows that Wuda granules (WDG), derived from the classical formula simo decoction, alleviate POI through coordinated actions on inflammation, epithelial barrier repair, intestinal pacemaker function, and gut microbiota remodeling. Multi-omics analysis revealed that WDG activates estrogen receptor signaling and enriches beneficial bacterial species linked to isovaleric acid production. These findings identify an inflammation-estrogen-microbiota axis as a key mechanism, supporting the therapeutic potential of WDG for POI management. |
| Citation |
Wang T, Xu YH, Ou YH, Xiong WJ, Luo LJ, Li J, Peng YH, Chen Y, Zeng HP, Yu Y, Tang HP, Wang F, Yao HL, Wang W. Wuda granules target estrogen receptors and modulate gut microbiota to alleviate postoperative ileus: A multi-omics perspective. World J Gastroenterol 2026; In press |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
