Publication Name	World Journal of Psychiatry
Manuscript ID	115996
Country	China

Category	Psychology, Multidisciplinary
Manuscript Type	Review
Article Title	Post-stroke depression update 2025: Mechanisms, prediction, and management
Manuscript Source	Invited Manuscript
All Author List	Jia-Xi Gu, Chao-Qiang Liu, Guang-Xi Chen, Tao Yao, Zhao-Xia Sun and Yong Wang
Funding Agency and Grant Number
Corresponding Author	Yong Wang, Researcher, Department of Internal Medicine, Yanbian University Hospital, No. 1327 Juzi Road, Yanji 133000, Jilin Province, China. wangyong0327ybu@163.com
Key Words	Post-stroke depression; Risk factors; Neuroinflammation; Gut-brain axis; Precision medicine
Core Tip	Post-stroke depression risk is refined by emerging biomarkers like vitamin D deficiency, hyperhomocysteinemia, and insulin resistance, alongside traditional factors. Multi-omics and artificial intelligence-driven models integrating clinical, neuroimaging, and inflammatory data show high predictive potential for precision stratification. Mechanistically, microglial/astrocytic polarization-driven neuroinflammation and gut-brain axis dysregulation are key therapeutic targets. Beyond first-line selective serotonin reuptake inhibitors, agomelatine, vitamin D supplementation, anti-inflammatory strategies, and evidence-based traditional Chinese medicine formulations that modulate neuro-immune crosstalk offer promising adjunctive treatments. A “predict-mechanism-intervene” paradigm is advocated to translate these advances into personalized management and improve long-term outcomes.
Citation	Gu JX, Liu CQ, Chen GX, Yao T, Sun ZX, Wang Y. Post-stroke depression update 2025: Mechanisms, prediction, and management. World J Psychiatry 2026; In press

Received	2025-10-31 05:41
Peer-Review Started	2025-10-31 05:41
First Decision by Editorial Office Director	2025-11-14 02:02
Return for Revision	2025-11-14 02:02
Revised	2026-01-09 18:18
Publication Fee Transferred
Second Decision by Editor	2026-02-02 03:01
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-02 04:58
Articles in Press	2026-02-02 04:58
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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