Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	116000
Country	Philippines

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Endoscopic clip systems for hemostasis and defect closure in gastrointestinal endoscopy
Manuscript Source	Invited Manuscript
All Author List	Enrik John T Aguila, Louis H S Lau, James Weiquan Li and Tyler M Berzin
Funding Agency and Grant Number
Corresponding Author	Enrik John T Aguila, MD, Institute of Digestive and Liver Diseases, St. Luke’s Medical Center Global City, Rizal Drive cor. 32nd St. and 5th Ave., Taguig City 1634, Metro Manila, Philippines. enjtaguila@stlukes.com.ph
Key Words	Clips; Endoscopy; Hemostasis; Closure; Through-the-scope; Over-the-scope clip; Bleeding; Perforation
Core Tip	Endoscopic clipping has evolved considerably, with modern through-the-scope clips and over-the-scope clips offering versatile, effective options for hemostasis and gastrointestinal defect closure. This article summarizes essential device features, comparative performance, and practical, evidence-based techniques for optimal clip selection and deployment. A clear understanding of clip anatomy, technical principles, and escalation thresholds is crucial for achieving durable closure, improving safety, and enhancing clinical outcomes.
Citation	Aguila EJT, Lau LHS, Li JW, Berzin TM. Endoscopic clip systems for hemostasis and defect closure in gastrointestinal endoscopy. World J Gastrointest Endosc 2026; In press

Received	2025-10-31 05:43
Peer-Review Started	2025-10-31 05:43
First Decision by Editorial Office Director	2025-11-18 09:57
Return for Revision	2025-11-18 09:57
Revised	2025-11-20 00:37
Publication Fee Transferred
Second Decision by Editor	2026-01-06 02:48
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-06 08:47
Articles in Press	2026-01-06 08:47
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5190 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
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