Publication Name	World Journal of Stem Cells
Manuscript ID	116004
Country	China

Category	Biochemistry & Molecular Biology
Manuscript Type	Basic Study
Article Title	Dysregulated circARF3/miR-27b-3p/YAP1 axis contributes to impaired osteogenic differentiation of periodontal ligament stem cells in periodontitis
Manuscript Source	Unsolicited Manuscript
All Author List	Lin Qi, Xiao-Qing Wang, Jia Sun, Rui-Zhi Li and Ze-Bin Mao
Funding Agency and Grant Number
Corresponding Author	Ze-Bin Mao, Department of Biochemistry and Biophysics, School of Basic Medical Sciences Peking University, No. 38 Xueyuan Road, Haidian District, Beijing 100191, China. zbmao@bjmu.edu.cn
Key Words	Periodontitis; Periodontal ligament stem cells; Osteogenic differentiation; Circular RNA; MicroRNAs; Yes associated protein 1
Core Tip	Periodontal ligament stem cells are promising candidate for the regenerative treatment of periodontal and alveolar bone tissues. Circular RNA ADP-ribosylation factor 3 was decreased in periodontal ligament tissues of periodontitis patients. Circular RNA ADP-ribosylation factor 3 promotes the osteogenic differentiation of periodontal ligament stem cells in periodontitis by acting as a sponge for miR-27b-3p and increasing the expression of its target gene, Yes associated protein 1. This suggests it could be a potential therapeutic target for regenerative treatment of periodontitis.
Citation	Qi L, Wang XQ, Sun J, Li RZ, Mao ZB. Dysregulated circARF3/miR-27b-3p/YAP1 axis contributes to impaired osteogenic differentiation of periodontal ligament stem cells in periodontitis. World J Stem Cells 2026; In press

Received	2025-11-25 09:06
Peer-Review Started	2025-11-25 09:06
First Decision by Editorial Office Director	2025-12-16 06:41
Return for Revision	2025-12-16 06:41
Revised	2026-01-07 11:20
Publication Fee Transferred	2026-01-29 10:10
Second Decision by Editor	2026-03-09 02:55
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-17 10:32
Articles in Press	2026-03-17 10:32
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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