Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	116006
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Gut-vascular barrier dysfunction in intestinal obstruction: The role of vagal suppression and heart rate variability
Manuscript Source	Invited Manuscript
All Author List	Meng-Qing Dong and Jiong Wu
Funding Agency and Grant Number
Corresponding Author	Jiong Wu, Associate Professor, Chief Physician, Department of Coloproctology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of TCM, No. 110 Ganhe Road, Hongkou District, Shanghai 200437, China. tcmoctober9@163.com
Key Words	Gut-vascular barrier; Heart rate variability; Intestinal obstruction; Plasmalemma vesicle associated protein 1; Vagus nerve
Core Tip	This article highlights a potentially overlooked mechanism - the role of the autonomic nervous system, particularly vagal tone, which may serve as a critical connection between intestinal obstruction and gut-vascular barrier disruption. Future research should investigate the link between heart rate variability and plasmalemma vesicle associated protein 1 expression, as integrating this non-invasive measure with a molecular marker could improve prognostication and reveal novel therapeutic avenues, such as vagus nerve stimulation.
Citation	Dong MQ, Wu J. Gut-vascular barrier dysfunction in intestinal obstruction: The role of vagal suppression and heart rate variability. World J Gastrointest Surg 2026; In press

Received	2025-10-31 05:45
Peer-Review Started	2025-10-31 05:45
First Decision by Editorial Office Director	2025-11-14 03:00
Return for Revision	2025-11-14 03:00
Revised	2025-11-21 15:16
Publication Fee Transferred
Second Decision by Editor	2026-01-19 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-19 03:25
Articles in Press	2026-01-19 03:25
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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