Publication Name	World Journal of Hepatology
Manuscript ID	116008
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Diagnostic efficacy and influencing factors of non-invasive liver fibrosis scores in chronic hepatitis B fibrosis: Cross-sectional study
Manuscript Source	Invited Manuscript
All Author List	Chun-Xia Wang, Pan Yan, Li-Juan Lan, Ben-Nan Zhao, Jun Kang, Mao-Quan Li and Da-Feng Liu
Funding Agency and Grant Number	Funding Agency Grant Number Scientific Research Project of Sichuan Provincial Medical Association S2024026 the Sichuan Traditional Chinese Medicine Administration Research Program 2024MS147 the Open Fund of Sichuan Provincial Key Laboratory of Philosophy and Social Sciences for Intelligent Medical Care and Elderly Health Management ZHYYZKZD2401
Corresponding Author	Da-Feng Liu, Professor, The First Ward of Internal Medicine, Public Health Clinical Center of Chengdu, No. 377 Jingming Road, Jinjiang District, Chengdu 610066, Sichuan Province, China. ldf312@126.com
Key Words	Chronic hepatitis B; Gamma-glutamyl transferase to platelet ratio; Fibrosis-4 index; Aspartate transaminase to platelet ratio index; Aspartate transaminase to alanine aminotransferase ratio; Child-Pugh classification; Nutritional risk
Core Tip	This investigation was carried out in Southwest China, where the diagnostic efficacy of four non-invasive liver fibrosis scoring tools [aspartate transaminase to platelet ratio index, fibrosis-4 index (FIB-4), gamma-glutamyl transferase to platelet ratio (GPR), and aspartate aminotransferase to alanine aminotransferase ratio] was comprehensively assessed. The results indicated that GPR and FIB-4 achieved optimal diagnostic precision for detecting significant fibrosis and cirrhosis; notably, GPR demonstrated the strongest association with FibroScan-derived liver stiffness measurements. Furthermore, the study revealed that diagnostic performance is influenced by gender, nutritional status, and Child-Pugh grade. These findings indicate that incorporating GPR and FIB-4 into routine clinical assessment, along with patient-specific characteristics, can improve early screening for liver fibrosis in chronic hepatitis B.
Citation	Wang CX, Yan P, Lan LJ, Zhao BN, Kang J, Li MQ, Liu DF. Diagnostic efficacy and influencing factors of non-invasive liver fibrosis scores in chronic hepatitis B fibrosis: Cross-sectional study. World J Hepatol 2026; In press

Received	2025-10-31 06:28
Peer-Review Started	2025-10-31 06:29
First Decision by Editorial Office Director	2025-12-09 07:27
Return for Revision	2025-12-09 07:27
Revised	2025-12-23 07:11
Publication Fee Transferred
Second Decision by Editor	2026-02-06 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-06 04:07
Articles in Press	2026-02-06 04:07
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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