Publication Name	World Journal of Gastroenterology
Manuscript ID	116016
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Peroxiredoxin 1 as a novel pyroptosis inducer in colorectal cancer: Insights and future directions
Manuscript Source	Unsolicited Manuscript
All Author List	Zi-Ke Chen, Jia-Wei Zhao, Wen-Ying Meng and Yu-Gang Wang
Funding Agency and Grant Number
Corresponding Author	Yu-Gang Wang, Chief Physician, Department of Gastroenterology, Shanghai Tongren Hospital, Shanghai Jiao Tong University School of Medicine, No. 1111 Xianxia Road, Shanghai 200336, China. wang_yugang@sina.com
Key Words	Colorectal cancer; Peroxiredoxin 1; Damage-associated molecular patterns; Pyroptosis; Gasdermin D
Core Tip	Pyroptosis is a key link of “cell death-anti-tumor immunity” in colon cancer, which not only directly suppresses tumor through gasdermin D-mediated cell lysis, but also releases inflammatory factors to remodel the immune microenvironment. In the future, advancing targeted pyroptosis strategies toward molecular intervention, deepening mechanistic insights, and validating multi-dimensional approaches will be crucial to address current challenges and improve outcomes in colon cancer treatment.
Citation	Chen ZK, Zhao JW, Meng WY, Wang YG. Peroxiredoxin 1 as a novel pyroptosis inducer in colorectal cancer: Insights and future directions. World J Gastroenterol 2025; In press

Received	2025-10-31 06:47
Peer-Review Started	2025-10-31 06:47
First Decision by Editorial Office Director	2025-11-25 09:30
Return for Revision	2025-11-25 09:30
Revised	2025-12-06 09:34
Publication Fee Transferred
Second Decision by Editor	2025-12-24 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-24 10:23
Articles in Press	2025-12-24 10:23
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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