Publication Name	World Journal of Psychiatry
Manuscript ID	116043
Country	China

Category	Medicine, Research & Experimental
Manuscript Type	Randomized Controlled Trial
Article Title	Short-term efficacy of cognitive behavioral therapy plus sertraline vs sertraline monotherapy for adolescent depression: A randomized controlled study
Manuscript Source	Unsolicited Manuscript
All Author List	Ling-Kai Yang, Ying Ye, Lang-Lang Cheng, Xiang Li, Zhai-Xiang Ye, Yan-Hui Zhu, Zhi-Yuan Lin and Xin-Liang Chen
Funding Agency and Grant Number	Funding Agency Grant Number Health Commission of Wenzhou No. Y20210768
Corresponding Author	Xin-Liang Chen, Chief Physician, Department of Child Psychiatry, Wenzhou Seventh People’s Hospital, No. 552 Xishan East Road, Ouhai District, Wenzhou 325000, Zhejiang Province, China. 15868592011@163.com
Key Words	Adolescent depression; Intervention; Children’s Depression Inventory; The Adverse Reaction Symptom Scale; Randomized controlled trial
Core Tip	This study showed that cognitive behavioral therapy based on ecological intervention combined with sertraline had better short-term efficacy than sertraline alone in the treatment of adolescent depression, and the safety profile was comparable. These results provide an empirical basis for the clinical selection of high-efficiency and low-risk adolescent depression treatment regimens. In the future, it is necessary to further verify the long-term effectiveness of the intervention, and explore comprehensive intervention strategies for comorbid factors such as sleep management and metabolic health.
Citation	Yang LK, Ye Y, Cheng LL, Li X, Ye ZX, Zhu YH, Lin ZY, Chen XL. Short-term efficacy of cognitive behavioral therapy plus sertraline vs sertraline monotherapy for adolescent depression: A randomized controlled study. World J Psychiatry 2026; In press

Received	2025-11-21 09:09
Peer-Review Started	2025-11-21 09:09
First Decision by Editorial Office Director	2025-12-12 07:39
Return for Revision	2025-12-12 07:39
Revised	2025-12-18 06:49
Publication Fee Transferred	2025-12-23 09:22
Second Decision by Editor	2026-02-10 02:48
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-10 05:58
Articles in Press	2026-02-10 05:58
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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