Publication Name	World Journal of Orthopedics
Manuscript ID	116046
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Basic Study
Article Title	Xianling Gubao capsule alleviates osteoporosis: Modulation of gut-bone axis and Wnt signaling
Manuscript Source	Unsolicited Manuscript
All Author List	Ao-Xue Yu, Wei-Hui Liang, Ya-Shuang Zhou, Pan Li, Jia-Mei Ji, Feng-Wei Zhang, Peng Yu and Jia Liu
Funding Agency and Grant Number	Funding Agency Grant Number the Science and Technology Department of Jilin Province - Jilin Provincial Science and Technology Development Plan Project 20250204060YY
Corresponding Author	Jia Liu, PhD, Office of Scientific Research, Changchun University of Chinese Medicine, No. 1035 Boshuo Road, Jingyue National High-tech Industrial Development Zone, Changchun 130117, Jilin Province, China. ccliujia1002@126.com
Key Words	Osteoporosis; Xianling Gubao capsule; Gut microbiota; Ovariectomized rats; Wnt/β-catenin
Core Tip	This study demonstrates that the Xianling Gubao capsule (XLGB) alleviates osteoporosis by modulating the gut-bone axis. Utilizing a multi-omics approach, we reveal that XLGB not only improves bone microstructure and serum bone markers but also rectifies ovariectomy-induced gut microbiota dysbiosis and metabolic disturbances. More importantly, we identify that its core mechanism involves the activation of the osteogenic Wnt/β-catenin pathway while simultaneously suppressing the adipogenic peroxisome proliferator-activated receptor gamma pathway, thereby rebalancing osteogenic-adipogenic differentiation in the bone marrow. This provides a novel mechanistic basis for XLGB’s anti-osteoporotic effects and underscores the gut-bone axis as a promising therapeutic target.
Citation	Yu AX, Liang WH, Zhou YS, Li P, Ji JM, Zhang FW, Yu P, Liu J. Xianling Gubao capsule alleviates osteoporosis: Modulation of gut-bone axis and Wnt signaling. World J Orthop 2026; In press

Received	2025-11-03 08:05
Peer-Review Started	2025-11-03 08:07
First Decision by Editorial Office Director	2025-11-10 07:04
Return for Revision	2025-11-10 07:04
Revised	2025-11-17 13:39
Publication Fee Transferred	2025-11-18 10:13
Second Decision by Editor	2026-01-09 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-09 14:12
Articles in Press	2026-01-09 14:12
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ISSN	2218-5836 (online)
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