Publication Name	World Journal of Stem Cells
Manuscript ID	116050
Country	China

Category	Cell Biology
Manuscript Type	Editorial
Article Title	Hypoxia-inducible factor-1α/β-catenin axis: A conserved regulatory hub for enhancing stem cell function in tissue regeneration
Manuscript Source	Invited Manuscript
All Author List	Hui-Fang Wang, Peng-Yu Yan, Shoaib Muhammad, Yu-Xiang Liu and Chun Liu
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Research Project of Basic Research Program in Shanxi Province 202203021221268 National Natural Science Foundation of China 82305030 Special Fund from Medicinal Basic Research Innovation Center of Chronic Kidney Disease, Ministry of Education, Shanxi Medical University CKD/SXMU-2024-04
Corresponding Author	Chun Liu, Chief Physician, Consultant, Dean, Professor, Department of Urology, First Hospital of Shanxi Medical University, No. 85 Jiefang South Road, Taiyuan 030001, Shanxi Province, China. sxtyliuchun@126.com
Key Words	Hypoxia-inducible factor-1α; β-catenin; Stem cell; Tissue regeneration; Conserved regulatory hub
Core Tip	The hypoxia-inducible factor-1α/β-catenin axis functions as a conserved regulatory hub that enhances stem cell survival and angiogenic capacity under hypoxic conditions. This unidirectional signaling pathway, with hypoxia-inducible factor-1α as the upstream driver, coordinates anti-apoptotic and pro-angiogenic responses in stem cells, offering a promising target for improving cell-based therapies in ischemic diseases such as myocardial infarction.
Citation	Wang HF, Yan PY, Muhammad S, Liu YX, Liu C. Hypoxia-inducible factor-1α/β-catenin axis: A conserved regulatory hub for enhancing stem cell function in tissue regeneration. World J Stem Cells 2026; In press

Received	2025-11-02 11:41
Peer-Review Started	2025-11-02 11:41
First Decision by Editorial Office Director	2025-11-28 07:46
Return for Revision	2025-11-28 07:46
Revised	2025-12-12 02:38
Publication Fee Transferred
Second Decision by Editor	2026-01-30 02:29
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-30 07:42
Articles in Press	2026-01-30 07:42
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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