Publication Name	World Journal of Diabetes
Manuscript ID	116053
Country	Mexico

Category	Endocrinology & Metabolism
Manuscript Type	Basic Study
Article Title	Association between high waist-height ratio and endoplasmic reticulum stress of young adults with insulin resistance
Manuscript Source	Invited Manuscript
All Author List	Oscar E Casillas, César A Hernández-Aguirre, Ana Gabriela Leija-Montoya, Tatiana Romero-García and J Gustavo Vázquez-Jiménez
Funding Agency and Grant Number	Funding Agency Grant Number Program of Universidad Autónoma de Baja California 106/2/C/27/25
Corresponding Author	J Gustavo Vázquez-Jiménez, MD, PhD, Departamento de Fisiología, Facultad de Medicina y Nutrición, Universidad Autónoma de Baja California, Centro Cívico, Mexicali 21000, Baja California, Mexico. gustavo.vazquez@uabc.edu.mx
Key Words	Endoplasmic reticulum stress; Insulin resistance; Waist-to-height ratio; Unfolded protein response; Adiposity
Core Tip	Insulin resistance (IR), a health complication commonly associated with advanced age, is increasingly affecting the young population due to poor eating habits and a sedentary lifestyle. In this study, conducted with 39 young adults, participants with a waist-to-height ratio greater than 0.5 showed elevated insulin levels, higher Homeostatic Model Assessment of Insulin Resistance, and altered body composition. Likewise, these participants exhibited platelet molecular disturbances, including IR and activation of proteins associated with endoplasmic reticulum stress. The results suggest that excessive central adiposity in the young population triggers early activation of molecular mechanisms underlying the development of metabolic diseases, such as type 2 diabetes mellitus.
Citation	Casillas OE, Hernández-Aguirre CA, Leija-Montoya AG, Romero-García T, Vázquez-Jiménez JG. Association between high waist-height ratio and endoplasmic reticulum stress of young adults with insulin resistance. World J Diabetes 2026; In press

Received	2025-11-02 11:09
Peer-Review Started	2025-11-07 00:39
First Decision by Editorial Office Director	2025-11-28 07:53
Return for Revision	2025-11-28 07:53
Revised	2025-12-12 02:09
Publication Fee Transferred
Second Decision by Editor	2026-01-13 00:18
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-30 04:13
Articles in Press	2026-01-30 04:13
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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