Publication Name	World Journal of Clinical Oncology
Manuscript ID	116093
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Immunotherapy in liver metastases: Challenges, emerging evidence, and future directions
Manuscript Source	Invited Manuscript
All Author List	Hoang Tran Pham, Zhong-Yi Dong, Margarita De Alba, Chasen Cottle, Ming-Yi Zhang, Joseph B Parker, Renee Morecroft-Phillipps, Keyur Chaludiya, Demarcus Ingram, Ayesha N Ahmad, Zhen Zeng, Michael M Mohseni, Zi-Zhen Zhang, Libardo Rueda Prada, Muhammad Ali and Vivienne Yang
Funding Agency and Grant Number
Corresponding Author	Vivienne Yang, MD, PhD, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, 4500 San Pablo Road South, Jacksonville, FL 32224, United States. vivienne.yang@proton.me
Key Words	Liver metastasis; Tumor microenvironment; Immune crosstalk; Cancer immunotherapy; Translational oncology
Core Tip	This review highlights how the liver’s unique vascular and immune environment fosters metastasis. We summarize key cellular interactions, the concept of the hepatic pre-metastatic niche, and emerging therapeutic strategies that may improve outcomes for patients with liver metastases.
Citation	Pham HT, Dong ZY, De Alba M, Cottle C, Zhang MY, Parker JB, Morecroft-Phillipps R, Chaludiya K, Ingram D, Ahmad AN, Zeng Z, Mohseni MM, Zhang ZZ, Rueda Prada L, Ali M, Yang V. Immunotherapy in liver metastases: Challenges, emerging evidence, and future directions. World J Clin Oncol 2026; In press

Received	2025-11-02 11:47
Peer-Review Started	2025-11-03 00:41
First Decision by Editorial Office Director	2025-11-26 09:31
Return for Revision	2025-11-26 09:31
Revised	2026-01-02 00:39
Publication Fee Transferred
Second Decision by Editor	2026-02-09 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-09 09:00
Articles in Press	2026-02-09 09:00
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
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