Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	116098
Country	Egypt

Category	Pediatrics
Manuscript Type	Observational Study
Article Title	Evaluation of heart rate variability in pediatric patients with beta thalassemia major: Cross-sectional study
Manuscript Source	Invited Manuscript
All Author List	Esraa A Sorour, Eman M Elaskary, Shimaa Basyoni Elnemr, Adel A Hagag, Nesma Ahmed Kassab and Mohammed Al-Beltagi
Funding Agency and Grant Number
Corresponding Author	Mohammed Al-Beltagi, Department of Pediatrics, Faculty of Medicine, Tanta University, 1 Hassan Radwan Street, Tanta 31511, Algharbia, Egypt. mohamed.elbeltagi@med.tanta.edu.eg
Key Words	β-thalassemia major; Heart rate variability; Autonomic dysfunction; Pediatric cardiology; Iron overload
Core Tip	Children with β-thalassemia major may develop cardiac dysfunction long before echocardiographic or clinical evidence appears. This study demonstrates that heart rate variability (HRV) analysis can detect early autonomic imbalance, reflecting subclinical cardiac involvement. Routine HRV monitoring in pediatric thalassemia patients offers a simple, non-invasive method to identify high-risk individuals and initiate preventive measures early, potentially improving cardiac outcomes and survival.
Citation	Sorour EA, Elaskary EM, Elnemr SB, Hagag AA, Kassab NA, Al-Beltagi M. Evaluation of heart rate variability in pediatric patients with beta thalassemia major: Cross-sectional study. World J Clin Pediatr 2026; In press

Received	2025-11-03 04:03
Peer-Review Started	2025-11-03 04:04
First Decision by Editorial Office Director	2025-12-09 09:26
Return for Revision	2025-12-09 09:26
Revised	2025-12-15 16:53
Publication Fee Transferred
Second Decision by Editor	2026-01-29 02:33
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-29 06:39
Articles in Press	2026-01-29 06:39
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2219-2808 (online)
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