Publication Name	World Journal of Diabetes
Manuscript ID	116113
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Letter to the Editor
Article Title	Optimizing platelet-rich plasma therapy for diabetic foot ulcers: From bench to bedside
Manuscript Source	Unsolicited Manuscript
All Author List	Wu Wei, Li-Rong Huang, Cong Wang and Zeng-Hui Lu
Funding Agency and Grant Number
Corresponding Author	Zeng-Hui Lu, Jiangxi University of Traditional Chinese Medicine, Jiangxi Hospital of Integrated Traditional Chinese and Western Medicine, Vascular Surgery,Jiangxi Province Hospital of Integrated Chinese and Western Medicine, Nanchang, Jiangxi, China, Nanchang 330003, Jiangxi Province, China. 1125488944@qq.com
Key Words	Diabetic foot ulcer; Platelet-rich plasma; Wound healing; Angiogenesis; Endovascular procedures
Core Tip	This commentary builds upon a recent study to propose key refinements for platelet-rich plasma (PRP) therapy in diabetic foot ulcers. We argue against a uniform PRP concentration, advocating instead for cell-type-specific formulations. Furthermore, we highlight the need to address diabetic endothelial dysfunction beyond angiogenesis, and to establish standardized, clinically-relevant protocols based on PRP bioactivity and precise patient stratification. These steps are crucial to transition PRP from a promising treatment to a reliably optimized and personalized therapeutic strategy.
Citation	Wei W, Huang LR, Wang C, Lu ZH. Optimizing platelet-rich plasma therapy for diabetic foot ulcers: From bench to bedside. World J Diabetes 2026; In press

Received	2025-11-02 11:11
Peer-Review Started	2025-11-03 10:29
First Decision by Editorial Office Director	2025-12-26 10:38
Return for Revision	2025-12-26 10:38
Revised	2025-12-29 17:30
Publication Fee Transferred
Second Decision by Editor	2026-01-16 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-16 07:03
Articles in Press	2026-01-16 07:03
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com