Publication Name	World Journal of Gastroenterology
Manuscript ID	116128
Country	Poland

Category	Gastroenterology & Hepatology
Manuscript Type	Case Control Study
Article Title	Gut bacterial and fungal signatures in relation to human leukocyte antigen-DQ2/DQ8 in children with celiac disease and siblings
Manuscript Source	Unsolicited Manuscript
All Author List	Dominika Salamon, Agnieszka Krawczyk, Barbara Zapała, Mariusz Duplaga, Kinga Kowalska-Duplaga and Tomasz Gosiewski
Funding Agency and Grant Number	Funding Agency Grant Number National Science Centre in Poland 2017/26/E/NZ5/00266
Corresponding Author	Tomasz Gosiewski, Full Professor, PhD, Department of Microbiology, Division of Molecular Medical Microbiology, Faculty of Medicine, Jagiellonian University Medical College, 18 Czysta Street, Cracow 31-121, Poland. tomasz.gosiewski@uj.edu.pl
Key Words	Bacteriobiota; Mycobiota; Microbial biomarkers; Microbiome sequencing; Celiac disease; Human leukocyte antigen-DQ2 /DQ8 alleles
Core Tip	This is the first comprehensive assessment of the bacteriobiome and mycobiome in children with celiac disease (CeD) and their first-degree relatives (siblings). Our findings highlight the potential of both bacterial and fungal signatures as early biomarkers of CeD susceptibility and suggest that host human leukocyte antigen genotypes, particularly DQ8 and DQ2.2, may shape the gut microbial landscape in children at risk for CeD, through both bacterial and fungal communities.
Citation	Salamon D, Krawczyk A, Zapała B, Duplaga M, Kowalska-Duplaga K, Gosiewski T. Gut bacterial and fungal signatures in relation to human leukocyte antigen-DQ2/DQ8 in children with celiac disease and siblings. World J Gastroenterol 2026; In press

Received	2025-11-06 07:42
Peer-Review Started	2025-11-06 07:43
First Decision by Editorial Office Director	2025-11-19 11:04
Return for Revision	2025-11-19 11:04
Revised	2025-12-06 10:01
Publication Fee Transferred	2025-12-10 16:48
Second Decision by Editor	2026-01-14 02:46
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-14 08:07
Articles in Press	2026-01-14 08:07
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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