Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	116163
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	ELF3 emerges as a novel prognostic indicator implicated in gastric cancer progression and correlated with unfavorable clinical outcomes
Manuscript Source	Unsolicited Manuscript
All Author List	Zong-Sheng Sun, Chang-Lei Li, Han-Hui Jing, Zheng-Zhao Wang and Long-Bo Zheng
Funding Agency and Grant Number
Corresponding Author	Long-Bo Zheng, MD, /, The Affiliated Hospital of Qingdao University, No. 1677 Wutai Street, Huangdao District, Qingdao 266000, Shandong Province, China. zhenglongbo2021@qdu.edu.cn
Key Words	E74-like ETS transcription factor 3; Stomach adenocarcinoma; Tumor; Prognosis; Immune infiltration; Biomarker
Core Tip	E74-like ETS transcription factor 3 (ELF3) is an epithelial transcription factor whose role in stomach adenocarcinoma (STAD) has been unclear. Integrating multi-database analyses with a 100-patient clinical cohort, we show that ELF3 is upregulated in STAD, independently predicts survival, and associates with immune-cell and chemokine infiltration. High ELF3 expression co-occurs with an immunosuppressive tumor microenvironment, suggesting a mechanism for disease progression. These findings position ELF3 as a practical prognostic biomarker and a rational therapeutic target to modulate antitumor immunity in STAD.
Citation	Sun ZS, Li CL, Jing HH, Wang ZZ, Zheng LB. ELF3 emerges as a novel prognostic indicator implicated in gastric cancer progression and correlated with unfavorable clinical outcomes. World J Gastrointest Oncol 2026; In press

Received	2025-11-06 07:40
Peer-Review Started	2025-11-06 08:18
First Decision by Editorial Office Director	2025-12-04 09:25
Return for Revision	2025-12-05 06:19
Revised	2025-12-18 20:37
Publication Fee Transferred	2025-12-25 14:50
Second Decision by Editor	2026-02-09 02:47
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-09 07:20
Articles in Press	2026-02-09 07:20
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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