Publication Name	World Journal of Gastroenterology
Manuscript ID	116173
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Targeting Dialister-driven succinate accumulation: A novel strategy for Crohn’s disease activity control and recurrence prevention
Manuscript Source	Invited Manuscript
All Author List	Sheng Xu, Zheng Zhu, Hui-Ming Zhang, Yue-Ting Xu, Pei-Hong Shi, Yang Zheng, Yi-Tong Chen, Guang-Rong Lu and Bin-Jiao Zheng
Funding Agency and Grant Number	Funding Agency Grant Number Zhejiang Province Medical and Health Science and Technology Plan Project 2024KY1239 Wenzhou Science and Technology Plan Project Y2023107 Talent Launch Project of Wenzhou Medical University KYYW202434
Corresponding Author	Bin-Jiao Zheng, PhD, Key Laboratory of Laboratory Medicine, Ministry of Education, Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, University Town, Chashan, Wenzhou 325000, Zhejiang Province, China. gusdy13x@wmu.edu.cn
Key Words	Crohn’s disease; Succinate; Therapeutic targets; Gut microbiota; Inflammatory bowel disease; Postoperative recurrence; Dialister
Core Tip	Crohn’s disease (CD) greatly affects patients’ quality of life, necessitating new treatment strategies. Boronat-Toscano et al examined the role of Dialister and succinate in CD by analyzing the fecal microbiota, circulating succinate levels, and clinical indices. They found that high succinate levels are linked to active CD and inflammation, with Dialister enrichment related to impaired succinate clearance and recurrence. These findings highlight succinate and Dialister as therapeutic targets, enhancing understanding of CD and guiding future research. Larger studies should validate these results, explore Dialister’s metabolic mechanisms, and develop treatments targeting the “succinate axis” to link basic research to clinical practice.
Citation	Xu S, Zhu Z, Zhang HM, Xu YT, Shi PH, Zheng Y, Chen YT, Lu GR, Zheng BJ. Targeting Dialister-driven succinate accumulation: A novel strategy for Crohn’s disease activity control and recurrence prevention. World J Gastroenterol 2025; In press

Received	2025-11-05 05:24
Peer-Review Started	2025-11-05 05:25
First Decision by Editorial Office Director	2025-11-25 09:31
Return for Revision	2025-11-25 09:31
Revised	2025-12-08 12:40
Publication Fee Transferred
Second Decision by Editor	2025-12-24 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-24 10:03
Articles in Press	2025-12-24 10:03
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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