Publication Name	World Journal of Methodology
Manuscript ID	116174
Country	Brazil

Category	Gastroenterology & Hepatology
Manuscript Type	Meta-Analysis
Article Title	Efficacy of duodenoscope with disposable distal cap in reducing microbial contamination: A systematic review and meta-analysis
Manuscript Source	Invited Manuscript
All Author List	Beanie Conceição Medeiros Nunes, Stefano Baraldo, Joao Ricardo Duda, Luiza Fenelon, Matheus Cavalcante Franco, Murilo Cavalcante Netto do Carmo, Diogo Bergesch Diedrich, Marcelo Cristalli Pacheco da Costa and Angelo So Taa Kum
Funding Agency and Grant Number
Corresponding Author	Angelo So Taa Kum, MD, Senior Researcher, Department of Gastroenterology Endoscopy Unit, Hospital das Clínicas, Faculty of Medicine, University of Sao Paulo, Av. Dr Enéas de Carvalho Aguiar, 225, 6o andar, bloco 3, Cerqueira Cesar, Sao Paulo 05403-010, SP, Brazil. angelo.kum@alumni.usp.br
Key Words	Duodenoscope with disposable distal cap; Standard duodenoscope; High-level disinfection; Microbial contamination; Systematic review; Meta-analysis
Core Tip	This systematic review and meta-analysis synthesize data from four randomized controlled trials, providing high-quality evidence that disposable distal caps are a highly effective solution to duodenoscope contamination. The primary finding demonstrates a 68% relative risk reduction in microbial contamination, as measured by adenosine triphosphate levels, following high-level disinfection when compared to standard duodenoscopes. This study strongly supports the adoption of disposable distal caps technology as a critical engineering control to enhance reprocessing safety and mitigate the transmission of healthcare-associated infections.
Citation	Nunes BCM, Baraldo S, Duda JR, Fenelon L, Franco MC, do Carmo MCN, Diedrich DB, da Costa MCP, Kum AST. Efficacy of duodenoscope with disposable distal cap in reducing microbial contamination: A systematic review and meta-analysis. 2026; World J Methodol In press

Received	2025-11-04 04:29
Peer-Review Started	2025-11-04 04:29
First Decision by Editorial Office Director	2025-11-14 07:58
Return for Revision	2025-11-14 07:58
Revised	2025-12-08 02:13
Publication Fee Transferred
Second Decision by Editor	2026-02-09 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-09 07:39
Articles in Press	2026-02-09 07:39
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2222-0682 (online)
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