Publication Name	World Journal of Stem Cells
Manuscript ID	116175
Country	United States

Category	Cell & Tissue Engineering
Manuscript Type	Basic Study
Article Title	Adipose-derived stem cell stimulation using poly-L-lactic acid injection
Manuscript Source	Unsolicited Manuscript
All Author List	Raheel Arshad Zubair, Xi-Han Zhou and Sabrina Guillen Fabi
Funding Agency and Grant Number	Funding Agency Grant Number an unrestricted educational grant from Galderma Laboratories; Fort Worth, TX, United States
Corresponding Author	Raheel Arshad Zubair, MD, Department of Research, Cosmetic Laser Dermatology, 9339 Genesee Avenue, Suite 300, San Diego, CA 92121, United States. raheel.zubair@platinumderm.com
Key Words	Poly-L-lactic acid; Macrophage polarization; Adipose-derived stem cells; Aging; Biomaterials; Biostimulatory agents
Core Tip	This study provides the first in vivo evidence that poly-L-lactic acid stimulates proliferation of cells expressing adipose-derived stem cell phenotype in human subcutaneous tissue. Using multiplex immunofluorescence on archived biopsy samples from a previous randomized clinical trial, poly-L-lactic acid-treated sites demonstrated marked expansion of cells exhibiting adipose-derived stem cell phenotype and fibroblasts in addition to a predominance of M2 macrophages consistent with a remodeling response. Most importantly, this may represent a novel regenerative paradigm using a minimally invasive technique.
Citation	Zubair RA, Zhou XH, Fabi SG. Adipose-derived stem cell stimulation using poly-L-lactic acid injection. World J Stem Cells 2026; In press

Received	2025-11-05 08:15
Peer-Review Started	2025-11-05 08:15
First Decision by Editorial Office Director	2025-11-25 07:46
Return for Revision	2025-11-25 07:46
Revised	2025-12-09 05:02
Publication Fee Transferred
Second Decision by Editor	2026-02-03 02:49
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-11 10:24
Articles in Press	2026-02-11 10:24
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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