Publication Name	World Journal of Diabetes
Manuscript ID	116185
Country	India

Category	Endocrinology & Metabolism
Manuscript Type	Letter to the Editor
Article Title	Clinical perspective on real-world switching patterns of glucagon-like peptide-1 receptor agonists in type 2 diabetes mellitus
Manuscript Source	Invited Manuscript
All Author List	Charan Neeradi, Vahini Golla, Archana Gaur and Sakthivadivel Varatharajan
Funding Agency and Grant Number
Corresponding Author	Sakthivadivel Varatharajan, Additional Professor, Department of General Medicine, All India Institute of Medical Sciences-Bibinagar, Bibinagar, Hyderabad 508126, Telangana, India. vsakthivadivel28@gmail.com
Key Words	Type 2 diabetes mellitus; Glucagon-like peptide 1 receptor agonists; Glycated hemoglobin; Glycemic control; Switching; Real-world
Core Tip	This large retrospective study of over 70000 people with type 2 diabetes reveals that one in four patients switched glucagon-like peptide 1 receptor agonists therapy. Remarkably, most achieved better blood sugar control, with average glycated hemoglobin dropping from 8.5% to 7.6%. The greatest benefit (81%) was seen when patients moved from daily to weekly injections, highlighting improved adherence and efficacy. These findings suggest that switching among glucagon-like peptide 1 receptor agonists – rather than escalating to more intensive regimens – may represent a practical, patient-centred alternative to therapeutic intensification in routine diabetes care.
Citation	Neeradi C, Golla V, Gaur A, Varatharajan S. Clinical perspective on real-world switching patterns of glucagon-like peptide-1 receptor agonists in type 2 diabetes mellitus. World J Diabetes 2026; In press

Received	2025-11-05 05:22
Peer-Review Started	2025-11-05 08:01
First Decision by Editorial Office Director	2025-12-23 10:08
Return for Revision	2025-12-23 10:08
Revised	2026-01-03 08:30
Publication Fee Transferred
Second Decision by Editor	2026-01-14 02:46
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-14 08:46
Articles in Press	2026-01-14 08:46
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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