Publication Name	World Journal of Gastroenterology
Manuscript ID	116187
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Modulation of the gut-liver axis by oxymatrine alleviates metabolic dysfunction-associated steatotic liver disease
Manuscript Source	Unsolicited Manuscript
All Author List	Jing-Fang Xiong, Ying He, Na Jiang, Yi-Hui Liu, Gao-Feng Chen, Chang-Qing Zhao, Shu-Yan Zhang, Yi-Jun Wu and Hong Xu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 82074100 Hangzhou Science and Technology Bureau No. 20201203B175 Scientific Research Fund for TCM in Zhejiang Province No. 2023ZL551 Scientific Research Fund for TCM in Zhejiang Province No. 2023ZL558
Corresponding Author	Hong Xu, Chief Physician, Department of Gastroenterology and Hepatology, Hangzhou Red Cross Hospital, No. 208 Huancheng Dong Road, Hangzhou 310003, Zhejiang Province, China. hongxuhzrc@aliyun.com
Key Words	Metabolic dysfunction-associated steatotic liver disease; Alcoholic liver disease; Metabolic dysfunction-associated steatohepatitis; Insulin resistance; Oxidative stress
Core Tip	Oxymatrine alleviates metabolic dysfunction-associated steatotic liver disease, primarily through modulation of the gut microbiome (increasing Lactobacillus, reducing Firmicutes/Bacteroidetes ratio) and the hepatic metabolome (increasing luteolin, decreasing adrenic acid). Fecal microbiota transplantation from oxymatrine donors recapitulated this protection, establishing a causal gut-liver axis for this natural alkaloid and offering a microbiota-guided therapeutic perspective.
Citation	Xiong JF, He Y, Jiang N, Liu YH, Chen GF, Zhao CQ, Zhang SY, Wu YJ, Xu H. Modulation of the gut-liver axis by oxymatrine alleviates metabolic dysfunction-associated steatotic liver disease. World J Gastroenterol 2026; In press

Received	2025-11-05 06:07
Peer-Review Started	2025-11-05 06:07
First Decision by Editorial Office Director	2025-12-02 10:13
Return for Revision	2025-12-02 10:13
Revised	2025-12-19 06:19
Publication Fee Transferred	2025-12-26 11:50
Second Decision by Editor	2026-02-09 02:47
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-09 07:07
Articles in Press	2026-02-09 07:07
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Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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