| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Review |
| Article Title |
Targeting sirtuins in diabetic retinopathy: Differential roles in inflammation and mitochondrial dysfunction
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Chen-Chen Pan, Qi-Qi Xie, Peng-Yu Lu, Zhen Shi, Hao-Yu Li, Yu-Jie Ma, Tian-Ye Ding, Mei-Qi Zeng, Cheng Luo and Fu-Yuan Zhuge |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Quzhou Science and Technology Program Project |
2022K69, 2025K049 |
| Henan Province Medical Science and Technology Research Program (Joint Construction) |
LHGJ20250403, LHGJ20220566, LHGJ20240365 |
| Henan Provincial Key Research and Development Program |
231111311000 |
| Henan Province Medical Education Research Project |
WJLX2023079 |
|
| Corresponding Author |
Fu-Yuan Zhuge, Chief Physician, MD, Professor, Department of Endocrinology, The First Affiliated Hospital of Shaoxing University, No. 568 Zhongxing North Road, Yuecheng District, Shaoxing 312000, Zhejiang Province, China. windee2002@163.com |
| Key Words |
Diabetic retinopathy; Inflammation; Mitochondrial dysfunction; Nuclear factor-κB; NLR family pyrin domain-containing 3 inflammasome; Sirtuins; Translational medicine |
| Core Tip |
This review summarizes the emerging roles of sirtuins (SIRT1-SIRT7) in diabetic retinopathy, emphasizing their regulatory functions in inflammation, oxidative stress, and mitochondrial dysfunction. By integrating evidence from molecular, cellular, and pharmacological studies, it highlights how selective activation of SIRT1 and SIRT3 restores retinal homeostasis. The review also outlines therapeutic advances in natural and small-molecule SIRT activators, providing a translational framework for multi-target interventions in diabetic retinopathy. |
| Citation |
Pan CC, Xie QQ, Lu PY, Shi Z, Li HY, Ma YJ, Ding TY, Zeng MQ, Luo C, Zhuge FY. Targeting sirtuins in diabetic retinopathy: Differential roles in inflammation and mitochondrial dysfunction. World J Diabetes 2026; In press |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
