Publication Name	World Journal of Diabetes
Manuscript ID	116210
Country	China

Category	Medicine, Research & Experimental
Manuscript Type	Editorial
Article Title	Synergistic mechanism of adipose-derived stem cells in healing diabetic foot ulcers
Manuscript Source	Invited Manuscript
All Author List	Xin-Xing Wan, Wei-Tao Yan, Wen-Hua He and Kun Xiong
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82572869 National Natural Science Foundation of China 82372507 National Natural Science Foundation of China 82172196 Natural Science Foundation of Hunan Province 2023JJ60015
Corresponding Author	Kun Xiong, Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, No. 172 Tongzipo Road, Changsha 410013, Hunan Province, China. xiongkun2001@163.com
Key Words	Diabetes; Diabetic foot ulcers; Mesenchymal stem cell; Adipose-derived stem cells; Inflammation
Core Tip	Although mesenchymal stem cells (MSCs) can be isolated and expanded from a variety of tissues, their regenerative efficacy for diabetic foot ulcers (DFUs) exhibits significant source-dependent variation, and the specific regulatory mechanisms involved remain incompletely understood. Cao et al demonstrated that subcutaneous injection of 5 × 105 adipose-derived stem cells (ADSCs) into the foot yielded the most effective wound healing outcomes for DFUs. Further angiogenesis experiments revealed that ADSCs promote blood vessel formation by activating the PI3K–AKT pathway to enhance VEGF secretion. Additionally, it was confirmed that ADSCs can suppress the overactivated Notch signaling pathway, thereby reducing local inflammatory responses and improving collagen deposition. This study not only elucidates the underlying molecular mechanisms by which ADSCs accelerate DFU healing but also provides critical evidence to support the clinical application of MSCs.
Citation	Wan XX, Yan WT, He WH, Xiong K. Synergistic mechanism of adipose-derived stem cells in healing diabetic foot ulcers. World J Diabetes 2026; In press

Received	2025-11-05 05:18
Peer-Review Started	2025-11-05 05:44
First Decision by Editorial Office Director	2025-12-09 07:16
Return for Revision	2025-12-09 07:16
Revised	2025-12-22 11:12
Publication Fee Transferred
Second Decision by Editor	2026-01-07 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-07 03:31
Articles in Press	2026-01-07 03:31
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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