Publication Name	World Journal of Stem Cells
Manuscript ID	116226
Country	Pakistan

Category	Cell Biology
Manuscript Type	Minireviews
Article Title	Stem cell derived exosomes: Emerging cell-free therapeutics for neurodegenerative disorders
Manuscript Source	Invited Manuscript
All Author List	Mahmood S Choudhery, Taqdees Arif, Ruhma Mahmood and David T Harris
Funding Agency and Grant Number
Corresponding Author	Mahmood S Choudhery, Associate Professor, Department of Human Genetics and Molecular Biology, University of Health Sciences, Khayaban-e-Jamia Punjab, Lahore 54000, Punjab, Pakistan. ms20031@yahoo.com
Key Words	Neurodegenerative diseases; Alzheimer’s disease; Parkinson’s disease; Stroke; Exosomes; Acellular therapy
Core Tip	Neurodegenerative disorders including Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and amyotrophic lateral sclerosis, are progressive and irreversible conditions marked by neuronal loss, misfolded protein accumulation, and severe cognitive or motor decline. Current therapies cannot halt neuronal death, and stem cell transplantation is limited by the blood-brain barrier. Exosomes, nanoscale vesicles secreted by cells, overcome this limitation by naturally crossing the blood-brain barrier, carrying proteins, nucleic acids, and lipids with neuroprotective potential. Their role in diagnosis, biomarker discovery, and targeted drug delivery highlights exosomes as promising acellular therapeutics for neurodegenerative disorders, with growing clinical interest and translational potential.
Citation	Choudhery MS, Arif T, Mahmood R, Harris DT. Stem cell derived exosomes: Emerging cell-free therapeutics for neurodegenerative disorders. World J Stem Cells 2026; In press

Received	2025-11-06 06:57
Peer-Review Started	2025-11-06 06:57
First Decision by Editorial Office Director	2025-12-09 07:20
Return for Revision	2025-12-09 07:20
Revised	2025-12-12 18:00
Publication Fee Transferred
Second Decision by Editor	2026-01-29 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-05 10:54
Articles in Press	2026-02-05 10:54
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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