| Category |
Surgery |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Plasma apolipoprotein A2 isoforms predict the development of pancreatic fistula following distal pancreatectomy
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Takashi Ono, Akira Matsushita, Daigo Yoshimori, Akira Hamaguchi, Takahiro Murokawa, Junji Ueda, Tetsuya Shimizu, Yoichi Kawano, Mampei Kawashima, Yoshiharu Nakamura, Kengo Nagashima, Ayumi Kashiro, Kazufumi Honda and Hiroshi Yoshida |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Scientific Research from the Japan Society for the Promotion of Science |
23K08141 |
| Japan Agency for Medical Research and Development |
25ama221431h0002 |
| Agency for Medical Research and Development Practical Research for Innovative Cancer Control |
25ck0106922h0002 |
|
| Corresponding Author |
Akira Matsushita, MD, PhD, Department of Gastroenterological Surgery, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku 113-8603, Tokyo, Japan. akira-matsushita@nms.ac.jp |
| Key Words |
Blood biomarker; Apolipoprotein A2-isoforms; Pancreatic fistula; Distal pancreatectomy; Pancreatic exocrine function |
| Core Tip |
Postoperative pancreatic fistula (POPF) is a major complication after distal pancreatectomy. This retrospective cohort study of 51 patients investigated the association between POPF and preoperative plasma apolipoprotein A2 isoforms, as a marker of pancreatic exocrine function. Patients with POPF had significantly higher apoA2-AT/AT levels than those without. Receiver operating characteristic analysis yielded an area under the curve of 0.802, with optimal cutoff value of 58.17 μg/mL calculated by Youden’s index. Levels above this threshold were independently associated with POPF. Thus, preoperative apolipoprotein A2 isoforms levels may help predict POPF risk, enabling better perioperative planning and personalized care for patients undergoing distal pancreatectomy. |
| Citation |
Ono T, Matsushita A, Yoshimori D, Hamaguchi A, Murokawa T, Ueda J, Shimizu T, Kawano Y, Kawashima M, Nakamura Y, Nagashima K, Kashiro A, Honda K, Yoshida H. Plasma apolipoprotein A2 isoforms predict the development of pancreatic fistula following distal pancreatectomy. World J Gastroenterol 2026; In press |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
