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Publication Name World Journal of Clinical Oncology
Manuscript ID 116251
Country Kyrgyzstan
Category Oncology
Manuscript Type Retrospective Cohort Study
Article Title Cancer stem cell markers, chemotherapy response, and survival in triple-negative breast cancer
Manuscript Source Unsolicited Manuscript
All Author List Faisal Nabi Depar, Ahmed Jamal Chaudhary, Jawad Hameed, Faisal Sarwar Abbasi, BiBi Uzma, Amjad Ali, Naheed Akhtar, Rizwan Khan, Afsheen Siddiqi and Sohail Riaz
Funding Agency and Grant Number
Corresponding Author Sohail Riaz, MD, Department of Medicine, International University of Kyrgyzstan, International School of Medicine, 6 Seven April Street, Bishkek 720054, Kyrgyzstan. sohailriaz552@gmail.com
Key Words Triple-negative breast cancer; Cancer stem cells; CD44; CD24; Aldehyde dehydrogenase 1; Chemotherapy response; Survival; Pakistan
Core Tip In a Pakistani triple-negative breast cancer cohort, the cancer stem cell phenotype (CD44 high/CD24 low/aldehyde dehydrogenase 1 positive) occurred in 10.2% of cases and independently predicted markedly lower pathological complete response (5.0% vs 51.8%) and shorter overall survival (hazard ratio = 4.35). These findings from a South Asian population with high triple-negative breast cancer burden support cancer stem cell marker integration into risk stratification for personalized therapy in resource-limited settings.
Citation Depar FN, Chaudhary AJ, Hameed J, Abbasi FS, Uzma B, Ali A, Akhtar N, Khan R, Siddiqi A, Riaz S. Cancer stem cell markers, chemotherapy response, and survival in triple-negative breast cancer World J Clin Oncol 2026; In press
Received
2025-11-06 14:01
Peer-Review Started
2025-11-06 14:01
First Decision by Editorial Office Director
2025-12-09 07:21
Return for Revision
2025-12-09 08:17
Revised
2025-12-11 20:33
Publication Fee Transferred
Second Decision by Editor
2026-01-14 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-01-14 08:28
Articles in Press
2026-01-14 08:28
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 2218-4333 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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