Publication Name	World Journal of Experimental Medicine
Manuscript ID	116252
Country	India

Category	Medicine, Research & Experimental
Manuscript Type	Basic Study
Article Title	Antidiabetic effects of Gymnema sylvestre and metformin co-therapy in a type 2 diabetic rat model
Manuscript Source	Invited Manuscript
All Author List	Ajay Kodiyatar, Akhilesh Mishra, Megh Singh Dhakad, Vandana Roy, Mirza Masroor Ali Beg and Niket Rai
Funding Agency and Grant Number
Corresponding Author	Niket Rai, MD, PhD, Professor, Department of Pharmacology, L N Medical College, Sarvadharam C-Sector, Kolar Road, Bhopal 462042, Madhya Pradesh, India. rainiket26@gmail.com
Key Words	Gymnema sylvestre; Metformin; Type 2 diabetes mellitus; Insulin resistance; Combination therapy
Core Tip	This study evaluates the antidiabetic effects of Gymnema sylvestre (GS) alone and in combination with metformin in a high-fat diet and streptozotocin-induced type 2 diabetic rat model. The combination therapy improved glycemic control, lipid profile, renal parameters, and body weight compared with GS alone, although metformin remained superior. These findings support the potential role of GS as an adjunct to standard metformin therapy in type 2 diabetes mellitus.
Citation	Kodiyatar A, Mishra A, Dhakad MS, Roy V, Beg MMA, Rai N. Antidiabetic effects of Gymnema sylvestre and metformin co-therapy in a type 2 diabetic rat model. World J Exp Med 2026; In press

Received	2025-11-10 15:15
Peer-Review Started	2025-11-10 15:17
First Decision by Editorial Office Director	2025-12-24 10:11
Return for Revision	2025-12-24 10:11
Revised	2026-01-06 15:01
Publication Fee Transferred
Second Decision by Editor	2026-02-14 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-14 07:30
Articles in Press	2026-02-14 07:30
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-315x (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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