Publication Name	World Journal of Gastroenterology
Manuscript ID	116258
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Reconsidering early-life bile acid amidation defect in environmental enteric dysfunction
Manuscript Source	Invited Manuscript
All Author List	Yu-Han Yang and Yuan Li
Funding Agency and Grant Number
Corresponding Author	Yuan Li, MD, Professor, West China Hospital, Sichuan University, No. 17 People’s South Road, Chengdu 610041, Sichuan Province, China. l13258389785@126.com
Key Words	Bile acid metabolism; Malnutrition; Environmental enteric dysfunction; Small intestinal bacterial overgrowth; Bangladesh
Core Tip	This study identifies a previously unrecognized defect in bile acid conjugation among Bangladeshi infants with environmental enteric dysfunction, linking altered bile acid metabolism to poor growth and intestinal inflammation. Elevated unconjugated primary bile acids were strongly associated with anthropometry. Further, the findings highlight a possible age-related delay in the maturation of bile acid conjugation pathways in impoverished children. This study may provide the initial insights for exploring novel therapeutic targets through bile acid pathways for treating malnourished children worldwide.
Citation	Yang YH, Li Y. Reconsidering early-life bile acid amidation defect in environmental enteric dysfunction. World J Gastroenterol 2026; In press

Received	2025-11-06 04:28
Peer-Review Started	2025-11-06 04:28
First Decision by Editorial Office Director	2025-12-09 09:53
Return for Revision	2025-12-09 09:53
Revised	2025-12-11 06:04
Publication Fee Transferred
Second Decision by Editor	2026-01-13 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-13 04:25
Articles in Press	2026-01-13 04:25
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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