Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	116259
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Beyond the gut barrier: The gut-vascular barrier emerges as a key player in intestinal obstruction
Manuscript Source	Invited Manuscript
All Author List	Wo-Xin Pi, Hang Xiong, Yun Gong and Rui-Tong Sun
Funding Agency and Grant Number
Corresponding Author	Yun Gong, Assistant Professor, Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Kunming Medical University, No. 374 Dianmian Avenue, Kunming 650000, Yunnan Province, China. 1109133007@qq.com
Key Words	The gut-vascular barrier; Intestinal obstruction; Plasmalemma vesicle-associated protein 1; Intestinal epithelial barrier; Barrier disruption
Core Tip	Zhang et al. demonstrate that intestinal obstruction (IO) disrupts the gut-vascular barrier (GVB), evidenced by elevated Plasmalemma vesicle associated protein 1 (PV1) expression, which correlates strongly with systemic infection, organ injury, and poor clinical outcomes. This pivotal study establishes PV1 as a novel biomarker for risk stratification and positions GVB integrity as a critical therapeutic target, redefining IO management from an epithelial barrier-centric model to a GVB-driven paradigm.
Citation	Pi WX, Xiong H, Gong Y, Sun RT. Beyond the gut barrier: The gut-vascular barrier emerges as a key player in intestinal obstruction. World J Gastrointest Surg 2026; In press

Received	2025-11-06 06:47
Peer-Review Started	2025-11-06 06:47
First Decision by Editorial Office Director	2025-11-11 07:25
Return for Revision	2025-11-11 07:25
Revised	2025-11-24 16:50
Publication Fee Transferred
Second Decision by Editor	2026-02-05 02:47
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-05 05:00
Articles in Press	2026-02-05 05:00
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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