| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Baseline hepatitis B surface antigen and cirrhosis predict extended interferon therapy in chronic hepatitis B: A retrospective study
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Fei Yan, Xiu-Lan Xue, Ying Guo, Qi-Ran Zhang, Rui-Rui You, Jia Shang, Xiao-Ping Wu, Jia-Wei Geng, Xiao-Hong Gao, Qing Ye, Jing Liang, Xiao-Yan Wang, Jian-Yong Zeng, Jing Chen, Yi-Cheng Lin, Xin-Yu Chen, Qin Du, Wei-Li Yin, Lei Liu, Fang Wang, Bai-Guo Xu, Wen-Hong Zhang and Hui-Ling Xiang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Tianjin Health Research Project (Key Project) |
No. TJWJ2024ZD004 |
|
| Corresponding Author |
Hui-Ling Xiang, Department of Gastroenterology and Hepatology, Tianjin University Central Hospital (Tianjin Third Central Hospital), Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Institute of Hepatobiliary Disease, No. 83 Jintang Road, Hedong District, Tianjin 300170, China. huilingxiang@163.com |
| Key Words |
Chronic hepatitis B; Clinical cure; Extended course of interferon; Hepatitis B surface antigen; Prediction model |
| Core Tip |
This study’s innovation lies in its exploration of the factors influencing extended interferon therapy (≥ 48 weeks) through multicenter cohort data, thereby avoiding the premature termination of potentially effective therapies and providing an evidence-based foundation for individualized treatment planning. For the first time, it incorporates baseline cirrhosis status and constructs a predictive model that integrates baseline hepatitis B surface antigen levels. The model demonstrated strong discriminatory ability in both the training cohort and the externally validated cohort. |
| Citation |
Yan F, Xue XL, Guo Y, Zhang QR, You RR, Shang J, Wu XP, Geng JW, Gao XH, Ye Q, Liang J, Wang XY, Zeng JY, Chen J, Lin YC, Chen XY, Du Q, Yin WL, Liu L, Wang F, Xu BG, Zhang WH, Xiang HL. Baseline hepatitis B surface antigen and cirrhosis predict extended interferon therapy in chronic hepatitis B: A retrospective study. World J Gastroenterol 2026; In press |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
