Publication Name	World Journal of Stem Cells
Manuscript ID	116298
Country	China

Category	Orthopedics
Manuscript Type	Prospective Study
Article Title	Prospective evaluation of autologous bone marrow-derived mesenchymal stem cell injection in meniscal injury
Manuscript Source	Unsolicited Manuscript
All Author List	Xiang Fu, Hui Song, Jiu-Song Wu and Xu Chen
Funding Agency and Grant Number	Funding Agency Grant Number Guangdong Basic and Applied Basic Research Foundation 2021A1515110882
Corresponding Author	Xu Chen, MD, Department of Arthroplasty, The Sixth Affiliated Hospital of Xinjiang Medical University, No. 39 Wuxing South Road, Tianshan District, Urumqi 830002, Xinjiang Uygur Autonomous Region, China. chenxu0041@126.com
Key Words	Bone marrow-derived mesenchymal stem cells; Meniscal injury; Regenerative medicine; Pain relief; Functional recovery; Magnetic resonance imaging T2 mapping
Core Tip	This prospective clinical study examined the therapeutic efficacy of autologous bone marrow-derived mesenchymal stem cell injections in patients with chronic meniscal injuries. Significant pain reduction and functional improvement were observed over 12 months. This was supported by enhanced Visual Analog Scale pain, International Knee Documentation Committee, and Lysholm scores, as well as magnetic resonance imaging T2 mapping, indicating enhanced meniscal tissue quality. The intervention proved to be safe, minimally invasive, and well-tolerated, suggesting that bone marrow-derived mesenchymal stem cell therapy could offer a viable regenerative option to surgery for chronic meniscal injuries. This approach may facilitate both structural restoration and clinical recovery.
Citation	Fu X, Song H, Wu JS, Chen X. Prospective evaluation of autologous bone marrow-derived mesenchymal stem cell injection in meniscal injury. World J Stem Cells 2026; In press

Received	2025-12-09 09:16
Peer-Review Started	2025-12-09 09:17
First Decision by Editorial Office Director	2025-12-30 05:44
Return for Revision	2025-12-30 05:44
Revised	2026-01-12 05:09
Publication Fee Transferred	2026-01-14 04:37
Second Decision by Editor	2026-02-05 02:49
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-12 10:40
Articles in Press	2026-02-12 10:40
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com