Publication Name	World Journal of Psychiatry
Manuscript ID	116335
Country	China

Category	Psychology
Manuscript Type	Retrospective Cohort Study
Article Title	Antidepressant-opioid combination for advanced cancer pain-depression comorbidity: Analysis of efficacy and associated determinants
Manuscript Source	Unsolicited Manuscript
All Author List	Jie Hou, Jun Li, Zhi-Ying Hao, Yun-E Li, Rui-Xue Zhang, Jiang-Kai Gong and Wen-Jing Zhang
Funding Agency and Grant Number	Funding Agency Grant Number Scientific Research Project Plan of Shanxi Provincial Health Commission 2025ZD111
Corresponding Author	Wen-Jing Zhang, MD, Department of Pharmacy, Shanxi Province Cancer Hospital, Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences, Cancer Hospital Affiliated to Shanxi Medical University, No. 3 Zhigongxincun Street, Xinghualing District, Taiyuan 030013, Shanxi Province, China. sxszlyyzwj@163.com
Key Words	Antidepressants; Opioids; Advanced cancer pain with comorbid depression; Therapeutic effectiveness; Determinants; Duloxetine; Oxycodone extended-release tablets
Core Tip	To alleviate cancer pain and depression in patients with advanced cancer, this study evaluates the efficacy and determinants of antidepressants (duloxetine) plus opioids (oxycodone extended-release tablets) in treating advanced cancer pain-depression comorbidity. Through several analyses and verifications, the proposed combination regimen was found to effectively relieve pain, mitigate negative emotions, reduce oxycodone dependence, increase β-endorphin levels, and improve patients’ sleep quality and overall quality of life.
Citation	Hou J, Li J, Hao ZY, Li YE, Zhang RX, Gong JK, Zhang WJ. Antidepressant-opioid combination for advanced cancer pain-depression comorbidity: Analysis of efficacy and associated determinants. World J Psychiatry 2026; In press

Received	2026-01-09 09:52
Peer-Review Started	2026-01-09 09:52
First Decision by Editorial Office Director	2026-01-20 05:46
Return for Revision	2026-01-20 05:46
Revised	2026-02-26 14:31
Publication Fee Transferred
Second Decision by Editor	2026-04-09 02:32
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-09 08:53
Articles in Press	2026-04-09 08:53
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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