Publication Name	World Journal of Gastroenterology
Manuscript ID	116350
Country	United States

Category	Medicine, General & Internal
Manuscript Type	Minireviews
Article Title	Misdiagnosis of alpha-gal syndrome as non-celiac gluten sensitivity or lactose intolerance: A diagnostic blind spot for clinicians
Manuscript Source	Invited Manuscript
All Author List	Ayoola Awosika and Prithvi Balaji
Funding Agency and Grant Number
Corresponding Author	Ayoola Awosika, MD, Department of Family Medicine, University of Illinois College of Medicine Peoria, 1 Illini Drive, Bloomington, IL 61601, United States. ayoolaawosika@yahoo.com
Key Words	Alpha-gal IgE; Non-celiac gluten sensitivity; Alpha-gal; Lone star tick; Food exposure allergy
Core Tip	Integrating alpha-gal syndrome into the differential diagnosis of unexplained postprandial gastrointestinal symptoms - particularly in individuals from or with travel to tick-endemic areas - is imperative. Awareness of the unique etiologic and immunologic underpinnings of alpha-gal syndrome provides clinicians with a framework to recognize atypical presentations. Concerted efforts are needed to refine diagnostic algorithms, including the judicious use of serum α-gal-specific IgE testing in appropriate clinical contexts, and to develop multidisciplinary pathways linking gastroenterology, allergy/immunology and nutrition.
Citation	Awosika A, Balaji P. Misdiagnosis of alpha-gal syndrome as non-celiac gluten sensitivity or lactose intolerance: A diagnostic blind spot for clinicians. World J Gastroenterol 2025; In press

Received	2025-11-10 05:36
Peer-Review Started	2025-11-10 05:36
First Decision by Editorial Office Director	2025-11-18 11:17
Return for Revision	2025-11-18 11:17
Revised	2025-11-18 17:01
Publication Fee Transferred
Second Decision by Editor	2025-12-08 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-08 07:55
Articles in Press	2025-12-08 07:55
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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