Publication Name	World Journal of Experimental Medicine
Manuscript ID	116383
Country	China

Category	Medicine, Research & Experimental
Manuscript Type	Minireviews
Article Title	Double-edged role of N6-methyladenosine reader YTH structural domain family protein 2 in neurological disorders: Molecular mechanisms and translational prospects
Manuscript Source	Invited Manuscript
All Author List	Yu-Meng Liu, Ming Liu, Hang Yuan and Bin Li
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82504755 Top-level Talents Support Program of Yangzhou University 137013152 the “Lv Yang Jin Feng” Outstanding Doctor of Yangzhou
Corresponding Author	Bin Li, Assistant Professor, PhD, Institute of Comparative Medicine, Yangzhou University, No. 88 Daxue South Road, Yangzhou 225009, Jiangsu Province, China. lib111701@163.com
Key Words	YTH structural domain family protein 2; N6-methyladenosine; Alzheimer’s disease; Parkinson’s disease; Glioblastoma
Core Tip	This mini-review synthesizes evidence that the N6-methyladenosine (m6A) reader YTH structural domain family (YTHDF) 2 exerts context-dependent, often bidirectional effects in neurodegeneration and glioma by directing degradation of m6A-marked transcripts. YTHDF2 is regulated by upstream axes and interacts functionally with m6A writers/erasers. Because its net effect depends on cell type, brain region, disease stage and target dosage, YTHDF2 constitutes both a mechanistic biomarker and a selectively tractable therapeutic target; advancing translation will require cell/region-resolved targetome mapping, longitudinal dynamics, and testing of conditional genetics, small molecules and antisense oligonucleotides.
Citation	Liu YM, Liu M, Yuan H, Li B. Double-edged role of N6-methyladenosine reader YTH structural domain family protein 2 in neurological disorders: Molecular mechanisms and translational prospects. World J Exp Med 2026; In press

Received	2025-11-10 03:00
Peer-Review Started	2025-11-10 03:00
First Decision by Editorial Office Director	2025-12-16 09:21
Return for Revision	2025-12-16 09:21
Revised	2025-12-23 13:56
Publication Fee Transferred
Second Decision by Editor	2026-02-11 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-11 08:07
Articles in Press	2026-02-11 08:07
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-315x (online)
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