Publication Name	World Journal of Gastroenterology
Manuscript ID	116386
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Qiweizhigan granule ameliorates metabolic dysfunction-associated steatohepatitis by modulating the galectin 3/tumor necrosis factor receptor-associated factor 6-mediated ferroptosis
Manuscript Source	Unsolicited Manuscript
All Author List	Yu-Nuo Yang, Yun-Hong Sun, Ming-Zhe Zhu, Yi-Rong Wang, Meng Li, Kai Wang, Jing Ma, Li Zhang, Dan Hu, Wen-Jun Zhou, Guang Ji and Yan-Qi Dang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 82530124 Digestive Diseases Committee of the Chinese Association of Traditional Chinese Medicine-The Youth Empowerment Program No. 202557-006 State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine No. LSLSKL20240127
Corresponding Author	Yan-Qi Dang, Institute of Digestive Diseases, China-Canada Center of Research for Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Fenglin Road Subdistrict, Shanghai 200032, China. yq_dang@shutcm.edu.cn
Key Words	Qiweizhigan granule; Metabolic dysfunction-associated steatohepatitis; Galectin 3; Tumor necrosis factor receptor-associated factor 6; Ferroptosis
Core Tip	This study reveals that galectin 3 plays a critical role in the progression of metabolic dysfunction-associated steatohepatitis by regulating ferroptosis through the tumor necrosis factor receptor-associated factor 6/glutathione peroxidase 4 axis. The traditional Chinese medicine Qiweizhigan granule significantly alleviates the progression of metabolic dysfunction-associated steatohepatitis by targeting the galectin 3/tumor necrosis factor receptor-associated factor 6/glutathione peroxidase 4 axis.
Citation	Yang YN, Sun YH, Zhu MZ, Wang YR, Li M, Wang K, Ma J, Zhang L, Hu D, Zhou WJ, Ji G, Dang YQ. Qiweizhigan granule ameliorates metabolic dysfunction-associated steatohepatitis by modulating the galectin 3/tumor necrosis factor receptor-associated factor 6-mediated ferroptosis. World J Gastroenterol 2026; In press

Received	2025-11-14 12:41
Peer-Review Started	2025-11-17 00:35
First Decision by Editorial Office Director	2025-12-24 10:29
Return for Revision	2025-12-24 10:29
Revised	2026-01-06 12:21
Publication Fee Transferred	2026-01-08 01:32
Second Decision by Editor	2026-02-13 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-13 04:11
Articles in Press	2026-02-13 04:11
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Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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