Publication Name	World Journal of Clinical Oncology
Manuscript ID	116390
Country	China

Category	Oncology
Manuscript Type	Editorial
Article Title	Role of claudin-6 in high-grade endometrial carcinoma: Implications for risk stratification and personalized treatment strategies
Manuscript Source	Invited Manuscript
All Author List	Chuang Cai, Jin-Man Chen, Zu-Xun Qiu and Shu-Qi Ren
Funding Agency and Grant Number	Funding Agency Grant Number Zhongshan Science and Technology Bureau 2023B1033
Corresponding Author	Shu-Qi Ren, Associate Research Scientist, Department of Laboratory Medicine, Zhongshan Integrated Traditional Chinese and Western Medicine Hospital, No. 10 Dexiu Road, Zhongshan 528467, Guangdong Province, China. shuchijen@163.com
Key Words	Claudin-6; High-grade endometrial carcinoma; Risk stratification; Therapeutic target; Prognosis
Core Tip	This editorial focuses on the expression and clinical importance of the tight junction protein claudin-6 (CLDN6) in high-grade endometrial carcinoma. It demonstrates that CLDN6 overexpression independently correlates with aggressive pathological characteristics and poor patient outcomes. These findings underscore CLDN6’s value as a prognostic biomarker and highlight its potential as a therapeutic target, opening new possibilities for improved risk stratification and personalized treatment strategies in high-grade endometrial carcinoma.
Citation	Cai C, Chen JM, Qiu ZX, Ren SQ. Role of claudin-6 in high-grade endometrial carcinoma: Implications for risk stratification and personalized treatment strategies. World J Clin Oncol 2025; In press

Received	2025-11-11 11:52
Peer-Review Started	2025-11-12 00:23
First Decision by Editorial Office Director	2025-11-24 12:38
Return for Revision	2025-11-24 12:38
Revised	2025-12-01 16:59
Publication Fee Transferred
Second Decision by Editor	2025-12-24 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-24 10:44
Articles in Press	2025-12-24 10:44
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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