Publication Name	World Journal of Psychiatry
Manuscript ID	116395
Country	China

Category	Neuroimaging
Manuscript Type	Letter to the Editor
Article Title	New neural perspective on suicidal behavior in adolescent depression: Specific amygdala subregional dysconnectivity with visual and socio-cognitive networks
Manuscript Source	Invited Manuscript
All Author List	Xiao-Yue Zhou, Xiao-Qi Gong and Quan-Feng Zhu
Funding Agency and Grant Number
Corresponding Author	Quan-Feng Zhu, Associate Chief Pharmacist, Director, Department of Psychiatry, Affiliated Xiaoshan Hospital, Hangzhou Normal University, No. 728 Yuercai North Road, Hangzhou 311200, Zhejiang Province, China. quanfengzhu@126.com
Key Words	Major depressive disorder; Adolescent; Suicide attempt; Amygdala; Functional connectivity
Core Tip	Adolescents with major depressive disorder and a history of suicide attempts exhibit reduced resting-state functional connectivity between the right lateral amygdala and visual association areas (bilateral occipital lobes), along with abnormal connections involving the parahippocampal gyrus and superior temporal gyrus. These neural patterns are further correlated with lower self-esteem and higher interpersonal stress, offering an integrated neurobiological model linking emotional regulation, self-evaluation, and environmental stress in adolescent suicidality. The findings highlight the potential of amygdala subregion-based analysis in identifying specific neural circuits associated with suicide risk, paving the way for future biomarker development and targeted interventions.
Citation	Zhou XY, Gong XQ, Zhu QF. New neural perspective on suicidal behavior in adolescent depression: Specific amygdala subregional dysconnectivity with visual and socio-cognitive networks. World J Psychiatry 2026; In press

Received	2025-11-17 03:53
Peer-Review Started	2025-11-17 07:24
First Decision by Editorial Office Director	2025-12-30 05:39
Return for Revision	2025-12-30 05:39
Revised	2026-01-08 14:11
Publication Fee Transferred
Second Decision by Editor	2026-02-10 02:48
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-10 04:50
Articles in Press	2026-02-10 04:50
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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