Publication Name	World Journal of Psychiatry
Manuscript ID	116408
Country	Italy

Category	Ophthalmology
Manuscript Type	Minireviews
Article Title	Beyond vision: The overlooked burden of depression in glaucoma patients
Manuscript Source	Invited Manuscript
All Author List	Matteo Capobianco, Francesco Cappellani, Marieme Khouyyi, Simonetta Gaia Nicolosi, Fabiana D’Esposito, Mutali Musa, Marco Battista, Piero Barboni, Caterina Gagliano and Marco Zeppieri
Funding Agency and Grant Number
Corresponding Author	Marco Zeppieri, Consultant, MD, PhD, Department of Ophthalmology, University Hospital of Udine, p. le S. Maria della Misericordia 15, Udine 33100, Italy. mark.zeppieri@asufc.sanita.fvg.it
Key Words	Glaucoma; Quality of life; Depression; Neurodegeneration; Eye-brain axis; Retinal ganglion cells; Circadian dysfunction; Mental health assessment
Core Tip	Depression is common in people with glaucoma and still too often missed. The slow loss of vision, the fear of blindness, reduced social participation, and the day-to-day burden of complex treatment plans all take a psychological toll and erode quality of life. When depressive symptoms are present, patients are less likely to adhere to medications, sustain self-care, or keep follow-up appointments - behaviors that, in turn, can worsen visual outcomes. Emerging evidence also points to shared biology between glaucoma and depression. Neuroinflammation, mitochondrial dysfunction, and dysregulation of the hypothalamic-pituitary-adrenal axis recurs across both conditions and may help explain their clinical co-occurrence. For these reasons, routine identification and management of depression should be part of glaucoma care: Addressing mental health is not ancillary - it is integral to protecting vision.
Citation	Capobianco M, Cappellani F, Khouyyi M, Nicolosi SG, D’Esposito F, Musa M, Battista M, Barboni P, Gagliano C, Zeppieri M. Beyond vision: The overlooked burden of depression in glaucoma patients. World J Psychiatry 2026; In press

Received	2025-11-11 12:00
Peer-Review Started	2025-11-11 12:01
First Decision by Editorial Office Director	2025-12-30 05:39
Return for Revision	2025-12-30 05:39
Revised	2026-01-05 15:28
Publication Fee Transferred
Second Decision by Editor	2026-02-10 02:48
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-10 04:44
Articles in Press	2026-02-10 04:44
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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