Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	116411
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Integrating immune-related metrics with personalize first-line immunochemotherapy in human epidermal growth factor receptor 2-negative advanced gastric cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Yu-Han Yang
Funding Agency and Grant Number
Corresponding Author	Yu-Han Yang, Assistant Professor, West China School of Medicine, Sichuan University, No. 17 People’s South Road, Chengdu 6100041, Sichuan Province, China. yyh_1023@163.com
Key Words	Gastric cancer; Programmed death ligand 1 inhibitor; Predictive model; Neutrophil-to-lymphocyte ratio; C-reactive protein-albumin-lymphocyte index; Efficacy
Core Tip	This study developed and validated a novel survival prediction model for advanced human epidermal growth factor receptor 2 negative gastric cancer patients receiving immunotherapy combined with chemotherapy. A retrospective analysis of 200 patients identified programmed death ligand 1 expression, microsatellite instability, tumor-node-metastasis stage, tumor differentiation, neutrophil-to-lymphocyte ratio, and C-reactive protein-albumin-lymphocyte index as independent prognostic factors. Based on these factors, nomogram models for progression-free survival and overall survival were constructed and validated using the concordance index and area under the curve. The results showed good discrimination ability in both the training and validation sets, indicating that the model effectively predicts patient survival outcomes and provides strong support for personalized treatment decisions.
Citation	Yang YH. Integrating immune-related metrics with personalize first-line immunochemotherapy in human epidermal growth factor receptor 2-negative advanced gastric cancer. World J Gastrointest Oncol 2026; In press

Received	2025-11-11 12:50
Peer-Review Started	2025-11-11 12:50
First Decision by Editorial Office Director	2025-12-17 08:03
Return for Revision	2025-12-17 08:03
Revised	2025-12-22 14:40
Publication Fee Transferred
Second Decision by Editor	2026-01-09 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-09 09:45
Articles in Press	2026-01-09 09:45
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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